Concurrent Autoimmune Neutropenia and Idiopathic Thrombocytopenic Purpura Associated with IgG4-related Diease

Internal Medicine
Yayoi ShimazuTatsuharu Ohno

Abstract

IgG4-related disease (IgG4RD) is a multi-organ disorder characterized by an elevated serum IgG4 level and IgG4-positive plasma cell infiltration of the affected organs, accompanied by tissue fibrosis and sclerosis. Although it can affect any organ, to our knowledge, no cases involving concurrent autoimmune neutropenia and thrombocytopenia have been reported. A 62-year-old man visited our hospital and was diagnosed with IgG4RD accompanied by interstitial pneumonitis, lymphadenopathy, and interstitial nephritis. During his clinical course, he developed autoimmune neutropenia and idiopathic thrombocytopenic purpura. Our case, invoving multiple hematological abnormalities, might help deepen our understanding of the pathophysiology of IgG4RD.

References

Mar 10, 2001·The New England Journal of Medicine·H HamanoK Kiyosawa
Sep 16, 2005·Pancreas·Hirotaka OharaTakashi Joh
Oct 7, 2005·Arthritis Research & Therapy·Franco CapsoniAlberto Zanella
May 24, 2007·Journal of Gastroenterology·Hirotaka OharaTakashi Joh
Mar 19, 2009·Autoimmunity Reviews·Mojtaba AkhtariEdmund K Waller
Sep 2, 2011·Modern Rheumatology·Hisanori UmeharaUNKNOWN Research Program for Intractable Disease by Ministry of Health, Labor and Welfare (MHLW) Japan G4 team
Feb 10, 2012·The New England Journal of Medicine·John H StoneVikram Deshpande
Dec 8, 2014·Lancet·Terumi KamisawaJohn H Stone
Oct 1, 2010·Clinical Journal of Gastroenterology·Hiroaki SawaiHiroyuki Ono
Oct 27, 2015·Immunological Reviews·Anna M Davies, Brian J Sutton
Mar 30, 2017·Frontiers in Immunology·Aurélie GradosNicolas Schleinitz

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

© 2022 Meta ULC. All rights reserved