Concurrent bilateral projection and activation of motor cortices in a patient with congenital mirror movements: a TMS study

Clinical Neurology and Neurosurgery
M PapadopoulouN Karandreas

Abstract

Mirror movements (MMs) are unintended and unnecessary movements accompanying voluntary activity in homologous muscles on the opposite side of the body, particularly in distal arm muscles. Congenital MMs may be sporadic or familial. Several mechanisms have been proposed to explain persistent congenital MMs. Hypothesis 1 assumes the existence of an ipsilateral corticospinal pathway, and Hypothesis 2 the activation of both motor cortices. We report a new case of congenital mirror movements in a healthy woman. Electromyographic recordings and focal transcranial magnetic stimulation (TMS) were used for neurophysiological evaluation. Voluntary contraction of either abductor pollicis brevis (APB) elicited mirror activation of the other APB. Focal TMS of either M1 elicited motor evoked potential (MEP) of normal latency and amplitude in both resting APB. TMS of the left cortex upon maximal contraction of the right APB and mirror contraction of the left APB produced interhemispheric inhibition (IHI) in the former and silent period (SP) in the later. The electrophysiological evaluation using transcranial magnetic stimulation provides evidence of the concurrent action of both mechanisms in this patient. The combination of more than one hyp...Continue Reading

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Citations

Apr 12, 2011·Journal of Motor Behavior·Patricia K AddamoNellie Georgiou-Karistianis
Sep 24, 2013·Brain : a Journal of Neurology·Cécile GalleaEmmanuel Roze
Jun 18, 2015·Frontiers in Neuroanatomy·Quentin WelniarzEmmanuel Roze
Sep 20, 2012·Current Opinion in Neurobiology·Jimmy Peng, Frédéric Charron
Mar 3, 2021·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Marianna PapadopoulouNikolaos Karandreas

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