Concurrent chemoradiotherapy for inoperable stage III non-small-cell lung cancer

Current Oncology Reports
Robert MacRae, Hak Choy

Abstract

Chemoradiotherapy has become the standard treatment for patients with locally advanced non-small-cell lung cancer on the basis of several large randomized trials. Despite an increase in median survival from 10 months with radiotherapy alone to 16 to 17 months with concurrent chemoradiotherapy, long-term survival in this disease remains modest at best. With the advent of new biologic agents targeting specific cellular pathways associated with malignant progression, combined-modality therapy has the potential to target tumors selectively with less toxicity.

References

Feb 20, 1992·The New England Journal of Medicine·C Schaake-KoningA Nijs
Dec 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H ChoyL Leone
Aug 30, 1994·International Journal of Radiation Oncology, Biology, Physics·R WollmanZ Fuks
Jun 1, 1993·Cancer·H ChoyD D Von Hoff
Oct 21, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H ChoyT Kennedy
Sep 2, 1999·Journal of the National Cancer Institute·L MilasP J Tofilon
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K FuruseY Ariyoshi
Oct 21, 2000·Seminars in Radiation Oncology·M R GreenC A Sherman
Jan 30, 2002·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael Thun
Feb 7, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Yusuf E ErdiEllen D Yorke
Mar 16, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Luhua WangXiangru Zhang

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Citations

Oct 28, 2005·Radiology·Reginald F MundenDavid J Stewart
Jul 3, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Theodoros TsakiridisJames R Wright
Jul 10, 2010·International Journal of Radiation Oncology, Biology, Physics·Toran SanliTheodoros Tsakiridis
Apr 26, 2005·Radiologic Clinics of North America·Reginald F Munden, John Bruzzi
Jun 14, 2006·Journal of Thoracic Imaging·John F Bruzzi, Reginald F Munden

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