Concurrent chemoradiotherapy was associated with a higher severe late toxicity rate in nasopharyngeal carcinoma patients compared with radiotherapy alone: a meta-analysis based on randomized controlled trials

Radiation Oncology
Cheng-Run DuChaosu Hu

Abstract

To investigate the incidence and risk of severe late toxicity with concurrent chemoradiotherapy (CCRT) in nasopharyngeal carcinoma patients. Eligible studies included prospective randomized controlled trials (RCTs) evaluating CCRT versus radiotherapy alone in patients with nasopharyngeal carcinoma and in which data on severe late toxicities were available. Random effects or fixed effect models were applied to obtain the summary incidence, relative risks (RRs) and 95% confidence intervals (CIs). Five RCTs with 1102 patients with NPC were included in this analysis. The summary incidence of overall severe late toxicities in patients receiving CCRT was 30.7% (95% CI, 18-47.2%) and the incidence of radiotherapy alone group was 21.7% (95% CI, 13.3-33.4%). The use of concurrent chemotherapy was associated with an increased risk of severe late toxicities, with a RR of 1.349 (95% CI, 1.108-1.643; P = 0.005). As for specific late toxicity, CCRT significantly increased the risk of ear deafness/otitis (RR = 1.567; 95% CI, 1.192-2.052), but other late toxicities were not significantly different. Patients receiving concurrent chemotherapy regimens with 3-week high-dose cisplatin (HC) have a higher risk of ear deafness/otitis (RR = 1.672; 95%...Continue Reading

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Citations

Jun 16, 2017·Cell Death & Disease·Chun-Mei KuangRan-Yi Liu
Jul 6, 2019·The Journal of International Medical Research·Chun WangJun Yan
Sep 26, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carlos Rodriguez-GalindoAlberto S Pappo
Oct 27, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhen SuFang-Yun Xie
Apr 11, 2020·Scientific Reports·Hui Min LeeLee Fah Yap
Jan 7, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yu-Pei ChenJun Ma

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