Concurrent chemoradiotherapy with cisplatin and fluorouracil for locally advanced hypopharyngeal carcinoma

Acta Oto-laryngologica
Mee Sun YoonJoon Kyoo Lee

Abstract

The concurrent administration of cisplatin and fluorouracil (CCRT) during radiotherapy after induction chemotherapy had better results than induction chemotherapy followed by radiotherapy alone (CT+RT) for overall survival, laryngeal preservation, and locoregional control in patients with locally advanced hyopharyngeal cancer. To report treatment results comparing CCRT with CT+RT in locally advanced hypopharyngeal cancer. Sixty-six consecutive patients treated with curative intent were analyzed retrospectively. Thirty-eight patients were treated with induction chemotherapy followed by definitive RT, and 28 patients with induction chemotherapy followed by concurrent chemoradiotherapy. All patients had more than three cycles of continuous infusion of cisplatin and 5-fluorouracil every 3 weeks. The median dose of irradiation was 70 Gy in the CT+RT group and 68.4 Gy in the CCRT group, respectively. The overall 5-year survival rates were 24% for the CT+RT group and 42% for the CCRT group (p=0.031). The 3-year pharyngolaryngectomy-free survival rates were 32% for the CT+RT group and 63% for the CCRT group (p=0.032). The 3-year locoregional control rate for CCRT was significantly better than that for the CT+RT (52% vs 23%, p=0.004). A...Continue Reading

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Citations

Jun 9, 2012·Medical Oncology·Doaa Ali Sharaf El DeenShawky Mahmoud El Morsy
May 21, 2010·Radiation Oncology·Valentina KrstevskaDusko Lukarski
Apr 22, 2011·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Dong-Soo LeeByung-Oak Choi
Mar 26, 2015·International Journal of Clinical Oncology·Tomohiro SakashitaSatoshi Fukuda
Sep 8, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Myung Woul HanSoon Yuhl Nam
Jun 3, 2020·Head & Neck·Karine A Al FeghaliDavid I Rosenthal
May 3, 2020·World Journal of Surgical Oncology·Yao-Te TsaiKai-Ping Chang
Apr 14, 2009·Current Opinion in Otolaryngology & Head and Neck Surgery

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