Concurrent chemoradiotherapy with vinorelbine plus split-dose cisplatin may be an option in inoperable stage III non-small cell lung cancer: a single-center experience

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Hüseyin MertsoyluÖzgür Özyılkan

Abstract

Concurrent chemoradiotherapy is the current standard treatment for inoperable stage III non-small cell lung cancer (NSCLC). In this study we aimed to investigate the efficacy and toxicity of CCRT with split dose of cisplatin (30 mg/m2) and vinorelbine (20 mg/m2) in patients with inoperable stage III NSCLC followed in our oncology clinic. Medical records of 97 patients with inoperable stage III NSCLC treated with concurrent chemoradiotherapy with cisplatin-vinorelbine were retrospectively analyzed. Cisplatin (30 mg/m2) and vinorelbine (20 mg/m2) were administered on days 1, 8, 22, and 29 during radiotherapy. Two cycles of consolidation chemotherapy were given. All patient data, including pathological, clinical, radiological, biochemical, and hematological data, were assessed retrospectively using our database system. Our study included 97 unresectable stage III NSCLC patients who were treated with CCRT. Median age was 58 years old (range 39-75) and 87 (89.7%) of the patients were men. ECOG performance score was 0-1 in 93 patients (95.9%). Squamous histology, the most common histology, was diagnosed in 46 patients (47.4%). Median follow-up time was 23.8 months. Median progression-free survival (PFS) and median overall survival ti...Continue Reading

References

Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K FuruseY Ariyoshi
Nov 27, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·J P van Meerbeeck
Aug 15, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kathy S AlbainRobert B Livingston
May 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David R GandaraUNKNOWN Southwest Oncology Group
Sep 15, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Petr ZatloukalLadislav Pecen
Aug 10, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chandra P BelaniWalter J Curran
Aug 10, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pierre FournelUNKNOWN Groupe Lyon-Saint-Etienne d'Oncologie Thoracique-Groupe Français de Pneumo-Cancérologie
Apr 4, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Everett E VokesUNKNOWN Cancer and Leukemia Group B
Jun 4, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yoichi NaitoYutaka Nishiwaki
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Sep 10, 2011·Journal of the National Cancer Institute·Walter J CurranJames D Cox

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Citations

Aug 2, 2016·Expert Opinion on Drug Delivery·Fanfei MengYoon Yeo
May 18, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ningyi MaGuoliang Jiang

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