Abstract
To investigate the tolerance and efficacy of a modified concurrent chemoradiation (CCRT) protocol for patients with invasive bladder cancer "unfit" for radical cystectomy. Twenty-three muscle-invasive bladder cancer patients who were unfit for or unwilling to receive radical cystectomy were enrolled in this study. All patients had transitional cell carcinoma of bladder, and distribution of stage was 14 (61%), 1 (4%), and 8 (35%) for T3a, T3b, and T4, respectively. This study included a relatively old-age population, with the median age being 75 and 70% of patients over 70 years old. Patients were treated with maximal transurethral resection of the bladder tumor followed by curative CCRT. The chemotherapy (C/T) regimen was comprised of cisplatin, 50 mg/m(2) intravenously (i.v.) on Day 1; 5-fluorouracil (5-FU), 500 mg/m(2)/day by continuous i.v. infusion on Days 1-3; and leucovorin, 50 mg/day by continuous i.v. infusion on Days 1-3. Chemotherapy course was repeated at 21-day intervals. The radiation dose was 44-45 Gy to whole pelvis and 60-61.2 Gy to bladder, with a daily fraction of 1.8-2 Gy. The completeness of the CCRT protocol was defined as patients receiving at least 55 Gy of radiotherapy to the whole bladder and at least t...Continue Reading
References
Jan 1, 1992·Urology·K I WishnowR J Babaian
Apr 19, 1990·The New England Journal of Medicine·D RaghavanJ P Richie
Jan 1, 1981·Cancer·A B MillerA Winkler
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·J D CoxT F Pajak
Sep 30, 1994·International Journal of Radiation Oncology, Biology, Physics·J DunstA Altendorf-Hofmann
Apr 2, 1993·International Journal of Radiation Oncology, Biology, Physics·W TesterE Hammond
Dec 23, 2000·The Journal of Urology·M H HussainH B Grossman
Aug 16, 2001·Cancer·Y MizutaniT Miki
Nov 7, 2001·The Journal of Urology·K Plna, K Hemminki
Dec 18, 2001·International Journal of Cancer. Journal International Du Cancer·A ZouhairR Miralbell
Feb 6, 2002·Pathology·R Chetty, B Clarke
Citations
May 26, 2007·World Journal of Urology·Udo NageleMarkus A Kuczyk
Sep 4, 2008·International Urology and Nephrology·Chang-Hsien LuChuang-Chi Liaw
Dec 17, 2008·La Radiologia medica·M TroianoS Parisi
Apr 7, 2004·Current Oncology Reports·Ronald D Ennis
Jun 27, 2013·PloS One·Roland NassimWassim Kassouf
Jan 1, 2008·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Udo NageleMarkus A Kuczyk
Jul 9, 2008·World Journal of Urology·Axel BexSimon Horenblas
Mar 15, 2014·International Urology and Nephrology·Jianan YeQianfeng Zhuang
Sep 12, 2014·Japanese Journal of Clinical Oncology·Toshiya MaebayashiUNKNOWN Working Subgroup of Urological Cancers in Japanese Radiation Oncology Study Group
Oct 24, 2012·Critical Reviews in Oncology/hematology·Orazio CaffoEnzo Galligioni
Oct 3, 2015·Clinical Genitourinary Cancer·Yin-Hsun FengKuei-Li Lin
May 1, 2007·International Journal of Radiation Oncology, Biology, Physics·Christian WeissClaus Rödel
Nov 15, 2011·International Journal of Urology : Official Journal of the Japanese Urological Association·Haruhito AzumaTakanobu Ubai
Mar 23, 2015·The Journal of Urology·Yun-Ching HuangChing-Fang Wu
Jan 15, 2014·International Journal of Radiation Oncology, Biology, Physics·Guy-Anne TurgeonWassim Kassouf
Jan 1, 2011·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Jamal KhaderAhmed Salem
Mar 13, 2014·European Urology·Guillaume PloussardWassim Kassouf
Dec 3, 2016·Scientific Reports·Yun-Ching HuangChia-Hsuan Lai
Dec 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Claus RödelRolf Sauer
Jan 6, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ananya ChoudhuryRichard A Cowan
Mar 1, 2017·International Journal of Radiation Oncology, Biology, Physics·Catherine ThompsonAnanya Choudhury
Apr 13, 2017·Drug Development and Industrial Pharmacy·Li Hong WangXin Che
Dec 31, 2016·Bladder Cancer·Tracy L RoseUNKNOWN Retrospective International Study of Cancers of the Urothelial Tract (RISC) Investigators