PMID: 9539558Apr 16, 1998Paper

Concurrent cisplatin, prolonged oral etoposide, and vincristine plus chest and brain irradiation for limited small cell lung cancer: a phase II study of the Southwest Oncology Group (SWOG-9229)

International Journal of Radiation Oncology, Biology, Physics
C R ThomasR B Livingston

Abstract

The primary objectives of the study were to evaluate the efficacy and safety of prolonged oral (PO) etoposide as part of cisplatin-based chemotherapy plus concurrent chest/brain irradiation induction, followed by CAV consolidation, in the treatment of patients with limited-stage small cell lung cancer (SCLC-LD) within a cooperative group setting. Fifty-six eligible patients with SCLC-LD received three 28-day cycles of cisplatin 50 mg/m2 i.v. (days 1, 8; 29, 36; and 57, 64), PO etoposide 50 mg/m2 (days 1-14, 29-42, and 57-70), and vincristine 2 mg i.v. (days 1, 29, and 57). Thoracic irradiation (TRT) was administered at 1.8 Gy in 25 daily fractions to a total dose of 45 Gy via an AP:PA arrangement, to begin concomitantly with induction chemotherapy. Prophylactic cranial irradiation (PCI) was started on day 15 of induction therapy. Fifteen daily fractions of 2.0 Gy were administered to the entire brain to a total dose of 30 Gy to finish at approximately the same time as TRT. Two 21-day cycles of consolidation cyclophosphamide 750 mg/m2 i.v., doxorubicin 50 mg/m2 i.v., and vincristine 2 mg i.v. (all on days 1 and 22), were given beginning on day 106 or week 16, from the start of induction therapy. Among 56 eligible patients, 93% h...Continue Reading

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Citations

Sep 12, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·C R ThomasD R Gandara
Oct 7, 2003·American Journal of Clinical Oncology·Paul OkunieffUNKNOWN Radiation Oncology Committee of the Southwest Oncology Group
Jun 3, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Lucyna KepkaKrzysztof Bujko
Aug 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Quynh-Thu LeUNKNOWN Southwest oncology group

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