Abstract
The optimal sequencing of adjuvant chemotherapy (CT) and radiation therapy (RT) in patients with early-stage breast cancer remains unclear. We retrospectively compared 485 patients treated with conservative breast surgery and postoperative whole-breast RT and six courses of CMF (cyclophosphamide 600 mg/m(2), methotrexate 40 mg/m(2), and 5-fluorouracil 600 mg/m(2)) with 300 patients who received postoperative CMF only and with 509 patients treated with postoperative whole-breast RT only. The mean radiation dose delivered was 50 Gy (range, 46-52 Gy) with standard fractionation. The boost dose was 6-16 Gy according to resection margins and at the discretion of the radiation oncologist. Acute and late RT toxicity were scored using respectively the Radiation Therapy Oncology Group and the Late Effects in Normal Tissues Subjective, Objective, Management and Analytic scale. A slightly higher Grade 2 acute skin toxicity was recorded in the concurrent group (21.2% vs. 11.2% of the RT only group, p < 0.0001). RT was interrupted more frequently in the CMF/RT group respective to the RT group (8.5% vs. 4.1%; p = 0.006). There was no difference in late toxicity between the two groups. All patients in the concurrent group successfully receive...Continue Reading
References
Jun 11, 1992·The New England Journal of Medicine·A HerskovicB Emami
Oct 1, 1984·American Journal of Clinical Oncology·T K BanerjeeC Jacoby
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·J D CoxT F Pajak
Mar 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·B J SlotmanA B Karim
May 23, 1996·The New England Journal of Medicine·A RechtJ R Harris
Dec 15, 1995·Cancer·W F HartsellA K Murthy
Jul 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C G MilrossL Milas
Oct 2, 1997·The New England Journal of Medicine·J RagazI A Olivotto
Apr 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W A PetersD S Alberts
Sep 7, 2000·International Journal of Radiation Oncology, Biology, Physics·J R BellonM M Austin Seymour
Dec 6, 2001·Journal of the National Cancer Institute·A G TaghianS N Powell
Jun 6, 2002·The Breast Journal·Youseff M HannaDavid A Decker
Sep 5, 2002·Cancer·Neil IsaacKatherine A Vallis
Feb 8, 2003·International Journal of Radiation Oncology, Biology, Physics·Fabian FehlauerWinfried Alberti
Mar 26, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C FaulV Vogel
Citations
Jul 14, 2009·Radiation Oncology·Alberto Alvarado-MirandaFernando Lara-Medina
Mar 23, 2011·La Radiologia medica·L LiviG Biti
Sep 28, 2010·The Breast : Official Journal of the European Society of Mastology·Marcin SinackiJacek Jassem
May 26, 2009·Clinical Oncology : a Journal of the Royal College of Radiologists·N S Bese
Mar 19, 2016·BMC Cancer·Roman MezencevJohn F McDonald
Apr 14, 2016·Journal of Cancer Research and Therapeutics·Ou HuangKunwei Shen
Aug 21, 2013·The Breast : Official Journal of the European Society of Mastology·Lena SharpMia Bergenmar