Concurrent cytomegalovirus glomerulitis and BK polyomavirus-associated nephropathy in a kidney allograft biopsy

Transplant Infectious Disease : an Official Journal of the Transplantation Society
I O ChikekaCinthia B Drachenberg

Abstract

A 58-year-old renal transplant recipient underwent biopsy 11 weeks post transplantation for increasing creatinine. The biopsy showed cytomegalovirus (CMV) glomerulitis together with BK polyomavirus (BKPyV)-associated nephropathy (PVAN). Treatment with intravenous ganciclovir and overall reduction in maintenance immunosuppression resulted in prompt resolution of the CMV glomerulitis, but with persistence of PVAN in a follow-up biopsy 4 weeks later. Stable creatinine and BKPyV viral clearance were observed at the last clinical visit 15 months post transplantation. This case exemplifies infectious glomerulitis, which requires differentiation from the more common glomerulitis caused by antibody-mediated allograft rejection. The morphological similarities and differences between BKPyV and CMV infections are discussed.

References

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Citations

Apr 20, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C B DrachenbergA Haririan
May 17, 2018·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Karel KrejciJosef Zadrazil
Oct 4, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ana Carina Ferreira, David Navarro
Feb 7, 2018·Transplantation Proceedings·P Yooprasert, P Rotjanapan

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