Concurrent infection with multiple human papillomavirus types among unvaccinated and vaccinated 17-year-old Norwegian girls

The Journal of Infectious Diseases
Ida LaakeLill Trogstad

Abstract

Whether type-specific human papillomavirus (HPV) infection influences the risk of acquiring infections with other HPV types is unclear. We studied concurrent HPV infections in 17-year-old girls from two birth cohorts; the first vaccine-eligible cohort in Norway and a pre-vaccination cohort. Urine samples were collected and tested for 37 HPV genotypes. This study was restricted to unvaccinated girls from the pre-vaccination cohort (n=5245) and vaccinated girls from the vaccine-eligible cohort (n=4904). Risk of HPV infection was modelled using mixed-effect logistic regression. Expected frequencies of concurrent infection with each pairwise combination of the vaccine types and high-risk types (6/11/16/18/31/33/35/39/45/51/52/56/58/59) were compared to observed frequencies. Infection with multiple HPV types was more common among unvaccinated girls than vaccinated girls (9.2% vs. 3.7%). HPV33 and HPV51 was the only HPV-pair that was detected together more often than expected among both unvaccinated (p=0.002) and vaccinated girls (p<0.001). No HPV-pairs were observed significantly less often than expected. HPV33 and HPV51 tended to be involved in co-infection among both unvaccinated and vaccinated girls. The introduction of HPV vacci...Continue Reading

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