Concurrent inhibition by tunicamycin of glycosylation and parasitemia in malarial parasites (Plasmodium falciparum) cultured in human erythrocytes

Pharmacology
I J Udeinya, K Van Dyke

Abstract

Tunicamycin (0.1--10 microgram/ml) incubated 96 h with human erythrocytes infected with malarial parasites significantly decreased parasitemia compared to controls. The antimalarial effect of tunicamycin was dose-related and paralleled its inhibition of the incorporation of radiolabeled glucosamine into parasite-derived membrane macromolecules. Tunicamycin had no significant effect on isoleucine incorporation into parasite-derived macromolecules. These results suggest that tunicamycin may act by inhibition of the glycosylation of parasite macromolecules. The results also indicate the role of glycosylated macromolecules in the survival of the erythrocytic stage of Plasmodium falciparum and the potential for selective inhibitors of the glycosylation of parasite macromolecules as agents for malarial chemotherapy.

Citations

Jan 1, 1992·Parasitology Research·A Dieckmann-SchuppertR T Schwarz
Dec 1, 1986·Experimental Parasitology·R D Walter
Oct 1, 1991·International Journal for Parasitology·Z KyossevR D Walter
Aug 1, 1985·Molecular and Biochemical Parasitology·T J Nolan, J P Farrell
Apr 15, 1992·European Journal of Biochemistry·A Dieckmann-SchuppertR T Schwarz
Jan 19, 2000·Parasitology Today·E A KimuraA S Couto
Jan 13, 2011·Memórias do Instituto Oswaldo Cruz·Cristiana S de MacedoLucia Mendonça-Previato
Jun 14, 1996·The Journal of Biological Chemistry·E A KimuraA M Katzin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.