Concurrent JAK2-Positive Myeloproliferative Disorder and Chronic Myelogenous Leukemia: A Novel Entity? A Case Report With Review of the Literature

Journal of Investigative Medicine High Impact Case Reports
Gilbert Bader, Bernard Dreiling

Abstract

JAK2 V617F mutation and BCR-ABL translocation have been considered to be mutually exclusive. However, many cases where both hits coexisted have been reported. We have personally managed a case too. We believe this hybrid entity is underdiagnosed. Thus, we decided to shed light on this "double hit" disease to improve its diagnosis and optimize its treatment. We reviewed the English literature in PubMed since JAK2 discovery. We found 33 cases reported so far. We summarized patient characteristics and analyzed possible interactions between JAK2 and BCR-ABL clones.

References

Oct 5, 2007·The Lancet Oncology·Monica BocchiaLauria Francesco
Mar 12, 2008·European Journal of Haematology·Simonetta PardiniMaurizio Longinotti
Jul 16, 2008·International Journal of Hematology·Monika Ribeiro Mello de ConchonIsrael Bendit
Jul 11, 2009·Leukemia Research·Leonardo CampiottiAchille Venco
Jan 5, 2010·International Journal of Hematology·Ping Chong BeeN Menaka
Sep 24, 2011·Blood·Lisa PieriAlessandro M Vannucchi
Jun 19, 2013·Leukemia & Lymphoma·Jyotsna MehtaRuben Mesa
Dec 3, 2013·International Journal of Hematology·Weiyi XuXiangmin Tong
Feb 12, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Osamu YamadaWilliam Vainchenker
Feb 7, 2015·Nigerian Medical Journal : Journal of the Nigeria Medical Association·Abdulaziz HassanAisha Indo Mamman

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Citations

Feb 12, 2021·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Rim FrikhaHassen Kamoun
May 9, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Sander De BruyneHenk Louagie

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