Concurrent Opioid and Benzodiazepine Utilization Patterns and Predictors Among Community-Dwelling Adults in the United States.

Psychiatric Services : a Journal of the American Psychiatric Association
Nina Vadiei, Sandipan Bhattacharjee

Abstract

Using benzodiazepines and opioids together substantially increases the risk of fatal overdose. Yet, concurrent benzodiazepine and opioid prescribing rates continue to increase amid the opioid overdose epidemic. Therefore, this study sought to identify patterns and predictors associated with self-reported concurrent benzodiazepine and opioid use among community-dwelling adults. This retrospective, cross-sectional study used Medical Expenditure Panel Survey data from 2011, 2013, and 2015. The study population included adults (age ≥18) who did not die during the calendar year. The dependent variable was concurrent benzodiazepine and opioid use, which was identified with Multum Lexicon therapeutic class codes. Multivariable logistic regression analysis was conducted to examine the association of various individual-level factors with concurrent benzodiazepine and opioid use. The final study sample consisted of 44,808 individuals (unweighted), of which 680 (1.6%) (weighted frequency=7,806,636) reported concurrent benzodiazepine and opioid use. Several individual-level factors were significantly associated with reporting use of this combination. For example, individuals with anxiety were more likely to report using both benzodiazepine...Continue Reading

References

Jul 1, 1997·Heart & Lung : the Journal of Critical Care·K PuntilloM Reid
Dec 30, 1999·Annals of Emergency Medicine·K H ToddL Goe
May 25, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ian Y LeongStephen J Gibson
Jan 4, 2008·The American Journal of Psychiatry·Maurizio FavaMadhukar H Trivedi
Jun 29, 2010·Journal of Pain and Symptom Management·Mark J EdlundMark D Sullivan
Apr 7, 2011·JAMA : the Journal of the American Medical Association·Amy S B BohnertFrederic C Blow
May 23, 2012·The Journal of Pain : Official Journal of the American Pain Society·Darrell J Gaskin, Patrick Richard
Aug 4, 2012·Drug and Alcohol Dependence·Jermaine D JonesSandra D Comer
May 31, 2013·Nature Reviews. Neuroscience·M Catherine BushnellLucie A Low
Aug 13, 2013·Postgraduate Medicine·Jeffrey A GudinSandra D Comer
Oct 21, 2014·PloS One·Eric W de HeerChristina M van der Feltz-Cornelis
Jul 15, 2015·Journal of Psychiatric Practice·Jeffrey GuinaRandon S Welton
Jul 20, 2016·Journal of Substance Abuse Treatment·Michael D SteinGenie L Bailey
Jun 15, 2017·Medical Care·Renu K GargGary M Franklin
Jul 10, 2017·The International Journal on Drug Policy·George Jay Unick, Daniel Ciccarone
Jul 12, 2017·BioSocieties·Julie Netherland, Helena Hansen
Jun 11, 2018·Psychiatry Research·Stanislav SpivakRamin Mojtabai
Aug 28, 2018·The Journal of Law, Medicine & Ethics : a Journal of the American Society of Law, Medicine & Ethics·Keturah James, Ayana Jordan
Jan 16, 2019·JAMA Network Open·Tara GomesDavid N Juurlink
Jan 27, 2019·JAMA Network Open·Sumit D Agarwal, Bruce E Landon
Feb 12, 2019·JAMA Internal Medicine·Bennett AllenDenise Paone
Mar 12, 2019·Population Health Management·Sarah GebauerF David Schneider

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Citations

Oct 17, 2020·The Mental Health Clinician·Nina VadieiJeannie K Lee

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