PMID: 6401458Jan 1, 1983Paper

Concurrent or sequential use of cytotoxic chemotherapy and hormone treatment in advanced breast cancer: report of the Swiss Group for Clinical Cancer Research

British Medical Journal
F CavalliK W Brunner

Abstract

In a trial of combined hormone treatment and cytotoxic chemotherapy 464 patients with advanced breast cancer were randomly allocated to either concurrent or sequential treatment. Cytotoxic drugs were given only if the antitumour activity of the hormone treatment was inadequate. Hormone treatment consisted of oophorectomy for premenopausal and tamoxifen administration for postmenopausal patients. Length of survival was better, though not significantly, in premenopausal patients (p = 0.29) treated concurrently and in postmenopausal women (p = 0.17) treated sequentially; the difference was highly significant (p = 0.003) only for postmenopausal women in the low-risk category. The findings suggest that postmenopausal women with metastatic breast cancer should probably be treated primarily by carefully monitored hormone treatment.

References

Dec 1, 1979·Annals of Internal Medicine·S S LeghaE J Freireich
Feb 1, 1982·American Journal of Clinical Oncology·D C TormeyT E Davis
Jan 1, 1981·Breast Cancer Research and Treatment·A H PatersonJ Hanson
Jan 10, 1980·The New England Journal of Medicine·I C Henderson, G P Canellos

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Citations

Nov 25, 2000·Breast Cancer : the Journal of the Japanese Breast Cancer Society·M Noguchi, K Miwa
Dec 1, 1985·Journal of Steroid Biochemistry·M R SertoliR Rosso
Dec 1, 1985·Journal of Steroid Biochemistry·F CavalliK W Brunner
Dec 1, 1985·Journal of Steroid Biochemistry·P F ConteB Drewinko
Jan 1, 1984·Pharmacology & Therapeutics·B J Furr, V C Jordan
Oct 1, 2013·The Breast : Official Journal of the European Society of Mastology·Ian E Smith, Gaia Schiavon
Nov 14, 1985·The New England Journal of Medicine·D T KiangB J Kennedy
Feb 1, 1985·Postgraduate Medical Journal·I E Smith
Feb 14, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Darren L StirlandYou Han Bae
Nov 17, 2009·The Breast : Official Journal of the European Society of Mastology·Ian E Smith, Susana Banerjee
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R D RubensR Paridaens
Apr 1, 1996·The Surgical Clinics of North America·T M LawM J Lopez
Dec 1, 1986·European Journal of Cancer & Clinical Oncology·H C Falkson, G Falkson
Sep 15, 1990·Cancer·I C HendersonJ R Harris
Nov 30, 1993·Annals of the New York Academy of Sciences·P PronzatoM Rosso
Nov 1, 1989·The Australian and New Zealand Journal of Surgery·J A SmithJ P Collins
Jan 1, 1988·Acta Oncologica·C Rose, H T Mouridsen
May 17, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M ColleoniA Goldhirsch

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