Concurrent Prophylactic Mastectomy, Immediate Reconstruction, and Salpingo-Oophorectomy in High-Risk Patients: A Case Series.

Plastic Surgery
Josephine A D'AbbondanzaMelinda A Musgrave

Abstract

There are limited data on coordinated breast and gynecological risk-reduction surgery for high-risk patients in Canada. Therefore, this study aims to evaluate the patient demographics, surgical details, and outcomes of prophylactic mastectomy (PM) with immediate reconstruction and bilateral salpingo-oophorectomy (BSO) in high-risk patients. We conducted a retrospective chart review at an academic center of patients who concurrently underwent PM with immediate reconstruction and laparoscopic BSO over a 7-year period (March 2010-February 2017) were identified. A total of 16 patients underwent PM with immediate reconstruction and concurrent BSO. The mean age at the time of surgery was 46.2 ± 6.6 years. Thirteen (81%) patients were carriers of the BRCA1 or BRCA2 mutation. Two patients had prophylactic surgical therapy for BRCA1 mutation and 14 (87.5%) patients had prior oncological treatment. The most common type of procedures performed were skin-sparing, nipple-sparing mastectomy (56.2%) and reconstruction with acellular dermal matrix and implants (43.8%). All patients underwent laparoscopic BSO. The average combined case time was 282.5 ± 81.3 minutes with an average postoperative hospital stay of 1.3 ± 0.5 days. Six (37.5%) patie...Continue Reading

References

Feb 1, 1986·Obstetrics and Gynecology·S C VossJ R Scott
Jan 14, 1999·The New England Journal of Medicine·L C HartmannR B Jenkins
Jul 21, 2001·The New England Journal of Medicine·H Meijers-HeijboerJ G Klijn
May 25, 2002·The New England Journal of Medicine·Timothy R RebbeckUNKNOWN Prevention and Observation of Surgical End Points Study Group
Oct 25, 2003·Science·Mary-Claire KingUNKNOWN New York Breast Cancer Study Group
Oct 28, 2004·American Journal of Obstetrics and Gynecology·Sean C DowdyLynn C Hartmann
Aug 24, 2006·Expert Review of Anticancer Therapy·Jessica I Goldberg, Patrick I Borgen
Feb 22, 2008·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Mar 26, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jan NorumPål Møller
Sep 18, 2008·ANZ Journal of Surgery·Peter WillsherLee Jackson
Jan 26, 2010·Annals of Plastic Surgery·William J CaseyPaul M Magtibay
Mar 11, 2010·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Nancie PetrucelliGerald L Feldman
Sep 3, 2010·JAMA : the Journal of the American Medical Association·Susan M DomchekTimothy R Rebbeck
Nov 9, 2011·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Jennica PlattToni Zhong
Sep 2, 2016·Annals of Surgical Oncology·Irene T MaBarbara A Pockaj
Dec 19, 2016·The Breast : Official Journal of the European Society of Mastology·Nicole IlonzoAye Moe Thu Ma

❮ Previous
Next ❯

Methods Mentioned

BETA
prophylactic surgery

Related Concepts

Related Feeds

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.