Abstract
The Mahuang-Xingren herb-pair (MX), the combination of Herba Ephedrae (Mahuang in Chinese) and Semen Armeniacae Amarum (Xingren in Chinese), is a classical combination used in traditional Chinese Medicine to treat asthma and bronchitis. A simple and reliable ultra-performance liquid chromatography-tandem mass spectrometry method was developed to simultaneously quantify and compare the pharmacokinetics of 5 ephedra alkaloids and epimers of amygdalin and prunasin in rat plasma after oral administration of Mahuang, Xingren, and MX aqueous extracts. Samples were pretreated by a single-step protein precipitation with acetonitrile, and diphenhydramine hydrochloride and puerarin were used as internal standards. Pharmacokinetic parameters were investigated using DAS 3.2.2 (Mathematical Pharmacology Professional Committee of China, Shanghai, China). The validated method demonstrated adequate sensitivity, selectivity, and process efficiency for the bioanalysis of 8 compounds, including 3 pairs of epimers. MX administration improved the bioavailability of amygdalin and prunasin. Furthermore, MX facilitated intake of lower doses of ephedra alkaloids and increased elimination rates in comparison with Mahuang alone. These results illustrate ...Continue Reading
References
Dec 16, 2000·The New England Journal of Medicine·C A Haller, N L Benowitz
Mar 28, 2007·Analytica Chimica Acta·Shogo MitsuhashiToshimasa Toyo'oka
Mar 2, 2010·Archives of Pharmacal Research·Ha-Jeong KwonSeon-Pyo Hong
Jun 22, 2010·Journal of Ethnopharmacology·Yu LiQing-chun Zhao
Jan 22, 2011·Electrophoresis·Lishuang YuGuonan Chen
Jul 12, 2011·Journal of Analytical Toxicology·Stephen D CooperBradley J Collins
Oct 18, 2011·Journal of Chromatography. a·James HeatonNorman W Smith
Nov 15, 2011·Journal of Pharmaceutical and Biomedical Analysis·E DeconinckJ O De Beer
Jan 24, 2012·Journal of Pharmaceutical and Biomedical Analysis·Lei ZhangAidi Qi
May 18, 2012·Journal of Pharmaceutical and Biomedical Analysis·Xiao-Dong WenPing Li
Jan 9, 2014·Immunopharmacology and Immunotoxicology·Shailendra Kapoor
Jan 22, 2014·Food Chemistry·Islamiyat F BolarinwaMichael R A Morgan
Feb 8, 2014·Journal of Pharmaceutical and Biomedical Analysis·Shun XiaoYiyu Cheng
Feb 15, 2014·Journal of Pharmaceutical and Biomedical Analysis·Xiaobing LiLi Ding
Jun 15, 2014·Journal of Ethnopharmacology·Ping WeiJia-bo Luo
Jul 26, 2014·Journal of Pharmaceutical and Biomedical Analysis·Weixia LiJin-ao Duan
Sep 11, 2014·Journal of Cancer Research and Therapeutics·Zuoqing Song, Xiaohong Xu
Oct 18, 2014·Journal of Analytical Toxicology·Shuai SongJiabo Luo
Mar 15, 2015·Journal of Pharmaceutical and Biomedical Analysis·Shuai SongJiabo Luo
Citations
Sep 8, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Guan-Ling XuGai-Mei She
Jan 1, 2016·Journal of Ethnopharmacology·Shuai SongJiabo Luo
Oct 17, 2015·Journal of Pharmaceutical and Biomedical Analysis·Gui-Zhong XinLi-Fang Liu
Jun 1, 2016·Bioanalysis·Zhanliang WangYouxuan Xu
Dec 24, 2015·Biomedical Chromatography : BMC·Shengnan WangXiaohui Chen
Aug 16, 2016·European Journal of Drug Metabolism and Pharmacokinetics·Yinghong TangYu He
Mar 15, 2015·Journal of Pharmaceutical and Biomedical Analysis·Shuai SongJiabo Luo
Jul 24, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daphne E González-JuárezElihú Bautista
Dec 21, 2017·Drug Metabolism Reviews·Peiying ShiHong Yao
Jan 31, 2020·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Hao LiuHouyin Shi
Dec 29, 2020·Journal of Ethnopharmacology·Jia-Xin MaWen-Hong Li
Aug 10, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jie ZhaoJie Liu
Dec 24, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yangang ChengMiaorong Pei
Nov 19, 2021·Analytical Methods : Advancing Methods and Applications·Shuru BaiLongshan Zhao