Concurrent quantification and comparative pharmacokinetic analysis of bioactive compounds in the Herba Ephedrae-Semen Armeniacae Amarum herb pair

Journal of Pharmaceutical and Biomedical Analysis
Shuai SongJia-bo Luo

Abstract

The Mahuang-Xingren herb-pair (MX), the combination of Herba Ephedrae (Mahuang in Chinese) and Semen Armeniacae Amarum (Xingren in Chinese), is a classical combination used in traditional Chinese Medicine to treat asthma and bronchitis. A simple and reliable ultra-performance liquid chromatography-tandem mass spectrometry method was developed to simultaneously quantify and compare the pharmacokinetics of 5 ephedra alkaloids and epimers of amygdalin and prunasin in rat plasma after oral administration of Mahuang, Xingren, and MX aqueous extracts. Samples were pretreated by a single-step protein precipitation with acetonitrile, and diphenhydramine hydrochloride and puerarin were used as internal standards. Pharmacokinetic parameters were investigated using DAS 3.2.2 (Mathematical Pharmacology Professional Committee of China, Shanghai, China). The validated method demonstrated adequate sensitivity, selectivity, and process efficiency for the bioanalysis of 8 compounds, including 3 pairs of epimers. MX administration improved the bioavailability of amygdalin and prunasin. Furthermore, MX facilitated intake of lower doses of ephedra alkaloids and increased elimination rates in comparison with Mahuang alone. These results illustrate ...Continue Reading

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Citations

Sep 8, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Guan-Ling XuGai-Mei She
Oct 17, 2015·Journal of Pharmaceutical and Biomedical Analysis·Gui-Zhong XinLi-Fang Liu
Aug 16, 2016·European Journal of Drug Metabolism and Pharmacokinetics·Yinghong TangYu He
Jul 24, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daphne E González-JuárezElihú Bautista
Jan 31, 2020·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Hao LiuHouyin Shi
Dec 29, 2020·Journal of Ethnopharmacology·Jia-Xin MaWen-Hong Li
Dec 24, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yangang ChengMiaorong Pei

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