Concurrent Quinidine and Phenobarbital in the Treatment of a Patient with 2 KCNT1 Mutations.

Current Therapeutic Research, Clinical and Experimental
Camerin C PasseyDavid M Denton

Abstract

Epilepsy of infancy with migrating focal seizures is a devastating pediatric neurologic disorder that often results in treatment-resistant seizure activity and developmental delay. The condition has been associated with mutations in the KCNT1 gene that cause a gain of function in neuronal sodium-activated potassium channels. Quinidine has been shown to reverse this gain of function and has recently been used to reduce seizure activity in patients with these mutations. We report the case of an infant with 2 KCNT1 mutations who experienced minor relief with quinidine and discuss the drug's important interaction with phenobarbital.

Citations

Jan 26, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Pasquale Striano, Berge A Minassian
Aug 11, 2020·Epilepsia·Sanjay M Sisodiya
Jun 3, 2021·Trends in Pharmacological Sciences·Bethan A ColeJonathan D Lippiat

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.