PMID: 2122886Sep 15, 1990Paper

Concurrent up-regulation of guanine-nucleotide-binding proteins Gi1 alpha, Gi2 alpha and Gi3 alpha in adipocytes of hypothyroid rats

The Biochemical Journal
G Milligan, E D Saggerson

Abstract

Rat white adipocytes express three distinct 'Gi-like' guanine-nucleotide-binding proteins (G-proteins) [Mitchell, Griffiths, Saggerson, Houslay, Knowler & Milligan (1989) Biochem. J. 262, 403-408]. We have previously noted elevated levels of Gi in membranes of adipocytes from hypothyroid rats [Milligan, Spiegel, Unson & Saggerson (1987) Biochem. J. 247, 223-227]. Using a series of anti-peptide antisera able to discriminate between the individual gene products we have examined levels of each Gi-like G-protein in adipocyte membranes of hypothyroid rats compared with euthyroid controls. We demonstrate that up-regulation of Gi in adipocytes of hypothyroid rats is not restricted to a single subtype of Gi but that each of Gi1 alpha, Gi2 alpha and Gi3 alpha is present at markedly higher levels compared with euthyroid animals. In contrast, levels of both the 45 and 42 kDa forms of Gs alpha were not altered substantially in the hypothyroid state.

Citations

Dec 1, 1992·The Proceedings of the Nutrition Society·R G Vernon
Feb 7, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G FrühbeckJ Salvador
Jan 5, 1993·Annals of the New York Academy of Sciences·T FülöpJ P Despont
Oct 1, 1996·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·F C LeungJ B Clark
Apr 6, 1993·Biochemical Pharmacology·M B Michel-ReherM C Michel
Jun 1, 1991·Trends in Pharmacological Sciences·G Milligan, A Green

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