Abstract
Substantial improvements in lipoprotein-lipid profiles have previously been shown with both simvastatin and combined estrogen-progestin therapy in postmenopausal hypercholesterolemic women. Since little is known about the impact of the concomitant use of these therapies, the effects of concurrent hormone therapy and simvastatin in hypercholesterolemic postmenopausal women have been evaluated. Twenty-three postmenopausal women with fasting serum total cholesterol levels greater than 250 mg/dl received, in a randomized cross-over design, simvastatin (10 mg daily) for 8 weeks or postmenopausal hormone therapy (up to 1.25 mg of conjugated equine estrogens plus 5 mg of medroxyprogesterone acetate daily) for 8 weeks, with an 8-week wash-out interval between the two treatment periods. In a third, non-randomized treatment period after a second wash-out interval, each woman received a combination of simvastatin and postmenopausal hormone therapy in the same dosage regimens as above. Fasting blood was sampled monthly from baseline to measure total cholesterol, high- and low-density lipoprotein (HDL and LDL) cholesterol, triglycerides and lipoprotein(a). For total cholesterol, the mean decreases with hormone therapy, simvastatin and combi...Continue Reading
References
Nov 1, 1992·Metabolism: Clinical and Experimental·A GranfoneE J Schaefer
Feb 1, 1992·Atherosclerosis·M P ColemanT A Sanders
Jan 11, 1991·The Journal of Clinical Investigation·G T EversonF Kern
Oct 1, 1986·Circulation·G H DahlenA M Gotto
Feb 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·P T KovanenM S Brown
Sep 1, 1983·The Journal of Clinical Investigation·M S Brown, J L Goldstein
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·S M Grundy, D W Bilheimer
Jul 1, 1995·Journal of Internal Medicine·S TonstadJ C Fruchart
Oct 15, 1994·Lancet·J E PedersenA Banning
Jul 1, 1994·European Journal of Clinical Investigation·P CremerD Seidel
Jun 16, 1993·JAMA : the Journal of the American Medical Association
Oct 3, 1996·The New England Journal of Medicine·F M SacksE Braunwald
Jun 9, 1997·Archives of Internal Medicine·M H DavidsonK B Drennan
Aug 28, 1997·The New England Journal of Medicine·G M DarlingS R Davis
May 21, 1998·Lancet·D R NairA F Winder
Aug 26, 1998·JAMA : the Journal of the American Medical Association·S HulleyE Vittinghoff
Aug 29, 1998·Obstetrics and Gynecology·A WakatsukiY Sagara
Jan 26, 1999·Circulation·K K KohR O Cannon
Citations
May 17, 2001·Menopause : the Journal of the North American Menopause Society·A O MueckD Wallwiener
Jul 10, 2003·Menopause : the Journal of the North American Menopause Society·Alfred O MueckDiethelm Wallwiener
Jan 19, 2008·Climacteric : the Journal of the International Menopause Society·A-M DupuyM-L Ancelin
Jun 1, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jian WuYoshiko Ishimi
Mar 23, 2005·Maturitas·Tatjana E VogelvangDieter Lütjohann
Jul 16, 2004·Metabolism: Clinical and Experimental·Jian WuYoshiko Ishimi
Oct 19, 2004·Atherosclerosis·André Arpad FaludiJose Eduardo M R Sousa
Mar 21, 2006·Metabolism: Clinical and Experimental·Jian WuYoshiko Ishimi
Dec 13, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yaprak Engin-UstünAyşe Kafkasli
May 29, 2002·Clinical Endocrinology·Juliet E Compston, Nelson B Watts
Mar 1, 2003·Clinical Endocrinology·Sonia Davison, Susan R Davis