Concurrent weekly cisplatin chemotherapy and radiotherapy in a haemodialysis patient with locally advanced cervix cancer

Clinical Oncology : a Journal of the Royal College of Radiologists
M A ZahraL T Tan

Abstract

Concurrent cisplatin chemo-radiotherapy improves outcome in cervical carcinoma. In haemodialysis patients, cisplatin is potentially hazardous. We report the treatment of a haemodialysis patient with cervix cancer using cisplatin-based chemo-radiation. Mathematical modelling using toxicity data from a range of cisplatin dosages and schedules reported in published studies was undertaken. The patient was treated using weekly cisplatin chemotherapy 25mg/m(2). The serum platinum levels were measured. Correlations between reported toxicity and platinum levels for a variety of cisplatin schedules in published studies were evaluated. Treatment was completed with no interruptions and minimum acute toxicity. The platinum levels rose progressively. The elimination half-life was prolonged at 6.6-7.5 days. The percentage extraction varied between 7.7 and 41.0%. The cumulative cisplatin dose correlated with neurotoxicity (P=0.002). Myelotoxicity correlated with the peak cisplatin level in the first 15 days of treatment (P=0.01). With an elimination half-life of 7.5 days, 35 mg/m(2) weekly is predicted to have the same risk of myelotoxicity and neurotoxicity as 40 mg/m(2) weekly in a patient with normal renal function. Weekly cisplatin chemot...Continue Reading

References

Jan 1, 1991·Cancer Investigation·N TanabeK Kimura
Jan 11, 1990·The New England Journal of Medicine·J E Mollman
Jul 5, 1990·The New England Journal of Medicine
Jan 1, 1986·Cancer Chemotherapy and Pharmacology·F BrivetJ Dormont
Jan 1, 1985·Annual Review of Medicine·D J Greenblatt
Apr 1, 1995·Therapeutic Drug Monitoring·R GorodetskyH Biran
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J L LagrangeG Milano
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G G ChabotS Chouaib
Apr 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W A PetersD S Alberts
Jan 1, 1993·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·P. Benedetti PaniciS. Mancuso
Jun 25, 2004·Clinical Oncology : a Journal of the Royal College of Radiologists·L T TanL Burgess
Apr 27, 2011·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Ian R RogersTamara Hew-Butler

❮ Previous
Next ❯

Citations

Dec 22, 2015·Cancer Chemotherapy and Pharmacology·Jennifer R EadsNeal J Meropol
Mar 14, 2009·Head & Neck·Ibrahim T AldossApar Kishor Ganti
Apr 28, 2017·Expert Review of Clinical Pharmacology·Verena GottaMarc Pfister
Aug 8, 2012·Onkologie·Irena LazarevWilmosh Mermershtain
Oct 12, 2018·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Hiroyuki AmagaiHisahiro Matsubara
Dec 18, 2019·BMC Cancer·Juan WangEmmanuel Kwateng Drokow

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.