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Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

Nature Genetics

Mar 18, 2012

Jian Ying YangPeter M Visscher

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Abstract

We present an approximate conditional and joint association analysis that can use summary-level statistics from a meta-analysis of genome-wide association studies (GWAS) and estimated linkage disequilibrium (LD) from a reference sample with individual-level genotype data. Using this met...read more

Mentioned in this Paper

Body Mass Index Procedure
Data Interpretation, Statistical
Diabetes Mellitus, Non-Insulin-Dependent
Genome, Human
Genetic Linkage
Linkage Disequilibrium
Nested Case-Control Studies
Variation (Genetics)
Cyclin-Dependent Kinase 4 Inhibitor B
Meta-Analysis (Publications)
11
1
690
Paper Details
References
    • References31
    • Citations186
    • References31
    • Citations186
  • Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

    Nature Genetics

    Mar 18, 2012

    Jian Ying YangPeter M Visscher

    PMID: 22426310

    DOI: 10.1038/ng.2213

    Abstract

    We present an approximate conditional and joint association analysis that can use summary-level statistics from a meta-analysis of genome-wide association studies (GWAS) and estimated linkage disequilibrium (LD) from a reference sample with individual-level genotype data. Using this met...read more

    Mentioned in this Paper

    Body Mass Index Procedure
    Data Interpretation, Statistical
    Diabetes Mellitus, Non-Insulin-Dependent
    Genome, Human
    Genetic Linkage
    11
    1
    690
    Paper Details
    References
    • References31
    • Citations186
    • References31
    • Citations186
  • Get paper from

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