journal cover

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

Nature Genetics

Mar 20, 2012

Jian YangPeter M Visscher

Abstract

We present an approximate conditional and joint association analysis that can use summary-level statistics from a meta-analysis of genome-wide association studies (GWAS) and estimated linkage disequilibrium (LD) from a reference sample with individual-level genotype data. Using this met...read more

Mentioned in this Paper

Genome-Wide Association Study
Diabetes Mellitus, Non-Insulin-Dependent
Meta-Analysis (Publications)
Meta Analysis (Statistical Procedure)
Dysequilibrium Syndrome
Cyclin-Dependent Kinase 4 Inhibitor B
CDKN2B protein, human
Body Mass Index Procedure
Data Interpretation, Statistical
Nested Case-Control Studies
11
1
727
Paper Details
References
  • References33
  • Citations243
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  • References33
  • Citations243
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Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

Nature Genetics

Mar 20, 2012

Jian YangPeter M Visscher

PMID: 22426310

DOI: 10.1038/ng.2213

Abstract

We present an approximate conditional and joint association analysis that can use summary-level statistics from a meta-analysis of genome-wide association studies (GWAS) and estimated linkage disequilibrium (LD) from a reference sample with individual-level genotype data. Using this met...read more

Mentioned in this Paper

Genome-Wide Association Study
Diabetes Mellitus, Non-Insulin-Dependent
Meta-Analysis (Publications)
Meta Analysis (Statistical Procedure)
Dysequilibrium Syndrome
Cyclin-Dependent Kinase 4 Inhibitor B
CDKN2B protein, human
Body Mass Index Procedure
Data Interpretation, Statistical
Nested Case-Control Studies
11
1
727

Similar Papers Found In These Feeds

Genetic Epidemiology Of Complex Diseases

Genetic epidemiology examines the role of genetic factors in determining health and disease in populations and the interaction between these genetic factors with environmental factors. Here is the latest research on the genetic epidemiology of complex multifactorial diseases like cancer.

The Nuffield Department of Medicine

Find the latest research from the Nuffield Department of Medicine at the University of Oxford here.

Related Papers

PLoS Genetics

Quantifying missing heritability at known GWAS loci

PLoS GeneticsJanuary 5, 2014
Alexander GusevAlkes L Price
Paper Details
References
  • References33
  • Citations243
1234
  • References33
  • Citations243
12345...
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