Conditional inactivation of noggin in the postnatal skeleton causes osteopenia.

Endocrinology
E CanalisStefano Zanotti

Abstract

Noggin is an antagonist of bone morphogenetic proteins (BMP), and its overexpression causes suppressed osteoblastogenesis and osteopenia. Global inactivation of Noggin results in severe developmental defects and prenatal lethality, but the consequences of the conditional inactivation of Noggin on the postnatal skeleton are not known. To study the function of noggin in osteoblasts, we generated tissue-specific null Noggin mice by mating Noggin conditional mice, where the Noggin allele is flanked by loxP sequences, with mice expressing the Cre recombinase under the control of the osteocalcin promoter (Oc-Cre). Noggin conditional null mice exhibited decreased weight, shortened femoral length, and generalized osteopenia. Bone histomorphometric and microarchitectural analyses of distal femurs revealed decreased bone volume due to a reduced number of trabeculae in 1- and 3-month-old Noggin conditional null mice. Vertebral microarchitecture confirmed the osteopenia observed in Noggin conditional null mice. Osteoclast number was increased in 1-month-old male Noggin conditional null mice, and bone formation was increased in 3-month-old mice, but female mice did not exhibit increased bone remodeling. In conclusion, Noggin inactivation ca...Continue Reading

References

Aug 1, 1988·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T L McCarthyE Canalis
Dec 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A M ParfittR R Recker
Jan 1, 1994·Critical Reviews in Eukaryotic Gene Expression·N Ghosh-ChoudhuryS E Harris
Apr 26, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E AbeS C Manolagas
Jun 28, 2000·Proceedings of the National Academy of Sciences of the United States of America·N K ShevdeJ W Pike
Mar 30, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P AspenbergA N Economides
Sep 8, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T R NagyJ Li
Nov 13, 2001·Developmental Cell·M MukhopadhyayH Westphal
Apr 25, 2002·Nucleic Acids Research·Irina NazarenkoAyoub Rashtchian
Jul 23, 2002·Nature Cell Biology·José G AbreuE M De Robertis
Mar 14, 2003·Bone·E GazzerroE Canalis
Apr 18, 2003·Endocrine Reviews·Ernesto CanalisElisabetta Gazzerro
Aug 9, 2003·The Journal of Endocrinology·D R Brigstock
Nov 13, 2004·Endocrinology·Elisabetta GazzerroErnesto Canalis
Oct 13, 2005·Journal of Cellular Biochemistry·Renata C PereiraErnesto Canalis
Jun 7, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Frederic MorvanGeorges Rawadi
Jul 4, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mina OkamotoNoriyuki Tsumaki
Oct 10, 2006·Reviews in Endocrine & Metabolic Disorders·Elisabetta Gazzerro, Ernesto Canalis
May 10, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Vaida GlattMary L Bouxsein
Jul 5, 2007·The Journal of Biological Chemistry·Derrick C WanMichael T Longaker
Sep 6, 2007·The Journal of Biological Chemistry·Elisabetta GazzerroErnesto Canalis
Feb 14, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Xiaodong LiChris Paszty
Feb 21, 2008·Journal of Cellular Biochemistry·Stefano ZanottiErnesto Canalis
May 8, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Julio E Sotillo RodriguezRajaram Gopalakrishnan
Oct 31, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nobuhiro KamiyaYuji Mishina
Mar 5, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Michael S OminskyChris Paszty
Mar 31, 2010·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Ernesto Canalis
Apr 9, 2010·The Journal of Clinical Endocrinology and Metabolism·Ernesto Canalis
Jun 10, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mary L BouxseinRalph Müller
Aug 6, 2010·The Journal of Clinical Endocrinology and Metabolism·Sundeep Khosla
Oct 21, 2010·Cellular Signalling·Beth BragdonAnja Nohe

❮ Previous
Next ❯

Citations

Feb 8, 2013·Nature Medicine·Roland Baron, Michaela Kneissel
Jul 5, 2012·Proceedings of the National Academy of Sciences of the United States of America·Marc Baud'huinPeter I Croucher
Apr 18, 2014·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·E KlinebergM C Gupta
Oct 22, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Hemanth AkkirajuAnja Nohe
Jul 22, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Steven K Pregizer, Douglas P Mortlock
Dec 23, 2014·Trends in Cell Biology·Saravana K RamasamyRalf H Adams
Jun 30, 2016·The New England Journal of Medicine·Pelin O Simsek KiperRoland Baron
Oct 28, 2016·Journal of Biomedical Materials Research. Part a·Ethan M LotzZvi Schwartz
Oct 22, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Xiaodan YuYasuhiko Kawakami
Mar 19, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Elise F MorganLouis C Gerstenfeld
Mar 22, 2014·Nature·Saravana K RamasamyRalf H Adams
Aug 30, 2018·Physiological Reviews·Jonathan W Lowery, Vicki Rosen
Jul 20, 2019·PLoS Genetics·Lea I MikkolaAntti Iivanainen
May 27, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Franziska LademannMartina Rauner
Aug 15, 2021·Seminars in Hematology·Maria G Ledesma-ColungaMartina Rauner
Dec 2, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lama IskandaraniBarbara F Hales

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.