Conditioned and unconditioned forelimb reflex systems in the cat: involvement of the intermediate cerebellum

Experimental Brain Research
F P KolbVlastislav Bracha

Abstract

Temporary inactivation of the cerebellar interposed nuclei was used to assess the role of the intermediate cerebellum in the performance of forelimb cutaneo-muscular reflexes in the cat. The following types of reflexive responses were evaluated: the classically conditioned and unconditioned forelimb withdrawal responses and the forelimb tactile placing, hopping and magnet responses. The experiments tested the hypothesis that the intermediate cerebellum is involved in the performance of all the above forelimb reflexes. The forelimb withdrawal reflex was classically conditioned in a newly developed paradigm in which animals were first operantly conditioned to stand on four elevated platforms. Trained animals were microinjected with a gamma-aminobutyric acid (GABA) agonist, muscimol, in the interposed nuclei, and the effects of inactivation of the intermediate cerebellar output on the forelimb reflexes were examined. The main findings of these experiments are that unilateral muscimol inactivation of the interposed nuclei in the cat abolished the expression of the classically conditioned limb flexion reflex, suppressed the performance of the unconditioned withdrawal reflex and, in parallel, down-regulated the tactile placing, hoppi...Continue Reading

Citations

Apr 9, 2013·The Cerebellum·Vincenzo PerciavalleRaudel Sánchez-Campusano
Mar 9, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Albena DimitrovaDagmar Timmann
Sep 1, 1998·Trends in Cognitive Sciences·W T Thach
Jul 16, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kris M HornAlan R Gibson
May 3, 2006·American Journal of Veterinary Research·Alessandra BergadanoClaudia Spadavecchia
May 17, 2002·The Journal of Physiology·Richard Apps, Stephen Lee
Jul 10, 2013·The Journal of Physiology·Paul DeanHenrik Jörntell
Nov 6, 2014·Scandinavian Journal of Medicine & Science in Sports·A R NeedleC B Swanik
Dec 5, 2003·Progress in Brain Research·Vlastislav Bracha
Dec 19, 2002·Neuroreport·Matthias MaschkeDagmar Timmann
Sep 28, 2002·Human Brain Mapping·Albena DimitrovaDagmar Timmann
Sep 14, 2012·Journal of Neurophysiology·A D CampbellM G Carpenter
Dec 6, 2003·Learning & Memory·Kimberly M Christian, Richard F Thompson

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