Conditioned aversion by amphetamine: rates of acquisition and loss of the attenuating effects of prior exposure.

Psychopharmacologia
H Cappell, A E Le Blanc

Abstract

Chronic prior treatment with amphetamine greatly attenuates the conditined aversion to saccharin that may be produced by amphetamine. Two experiments were designed to determine some of the limiting conditions of this phenomenon. In Experiment 1, chronic treatment with 7.5 mg/kg of amphetamine was administered for 0, 1, 5, or 20 days prior to pairing saccharin with an injection of 1.0 mg/kg of d-amphetamine sulphate. The results indicate that between 5 and 20 days of treatment were necessary for the treatment to be effective in attenuating conditioned aversion. In Experiment 2, rats were withdrawn from treatment with 20 mg/kg of amphetamine for 1, 7, or 14 days prior to conditioning trials with 1.0 mg/kg of amphetamine. The prior treatment lost it effectiveness in attenuating conditioned aversion between 7 and 14 days after withdrawal. Although alternative explanations are possible, the time intervals required for acquisition and loss of the effectiveness of prior treatment are consistent with the hypothesis that tolerance is the mechanism underlying the observed effects.

References

Jun 1, 1975·Journal of Comparative and Physiological Psychology·H CappellS Herling
Jul 1, 1974·Journal of the Experimental Analysis of Behavior·C Iglauer, J H Woods
Oct 1, 1974·Journal of Comparative and Physiological Psychology·A E LeBlanc, H Cappell
Feb 1, 1973·Journal of Comparative and Physiological Psychology·L ParkerK Weidman
Oct 1, 1973·Journal of Comparative and Physiological Psychology·H Cappell, A E Le Blanc
Jun 1, 1974·Physiology & Behavior·R F Berman, D S Cannon
Oct 1, 1972·Journal of Comparative and Physiological Psychology·B D Berger

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Citations

Jan 1, 1977·Pharmacology, Biochemistry, and Behavior·D S CannonR F Berman
Jan 1, 1979·Pharmacology, Biochemistry, and Behavior·Z W BrownG Rockman
Feb 1, 1982·Pharmacology, Biochemistry, and Behavior·R W Foltin, C R Schuster
May 1, 1983·Pharmacology, Biochemistry, and Behavior·D B Miller, L L Miller
Apr 1, 1984·Pharmacology, Biochemistry, and Behavior·K L PrestonC R Schuster
Sep 1, 1990·Brain, Behavior, and Immunity·M A Segall, L S Crnic
Sep 6, 2002·Pharmacology, Biochemistry, and Behavior·Ivana Grakalic, Anthony L Riley
Oct 1, 1980·Behavioral and Neural Biology·G J Fischer, B J Vail
Mar 6, 2010·Annals of the New York Academy of Sciences·Catherine M Davis, Anthony L Riley
Jan 1, 1985·Annals of the New York Academy of Sciences·E GamzuE Boff
Jan 1, 1987·Neuroscience and Biobehavioral Reviews·T Hunt, Z Amit
Feb 22, 2012·Pharmacology, Biochemistry, and Behavior·Bradley Wetzell, Anthony L Riley
Dec 1, 1978·Behavioral Biology·N Y Walton, J A Deutsch
Feb 1, 1989·Pflügers Archiv : European journal of physiology·K NazarW Pilis
Jun 1, 1996·Journal of Child Language·F Franco, G Butterworth
Jun 1, 1995·Journal of Child Language·T Rome-Flanders, C Cronk
Oct 1, 1994·Journal of Child Language·D Bassano, I Mendes-Maillochon
Oct 21, 2009·Developmental Science·Evan Kidd, Judith Holler
Jun 1, 1987·Journal of Child Language·H Marcos
Oct 1, 1986·Journal of Child Language·R M Golinkoff
Feb 1, 1983·Journal of Child Language·L Olsen-Fulero
Jun 1, 1981·Journal of Child Language·R M Golinkoff
Oct 1, 1981·Journal of Child Language·L S SnyderI Bretherton
Feb 1, 1980·Journal of Child Language·P S Dale
Dec 17, 2010·Developmental Science·Anke F BullingerMichael Tomasello
Oct 26, 2011·American Journal of Primatology·Christel SchneiderKatja Liebal
Oct 31, 2012·Developmental Science·Danielle MatthewsMichael Tomasello
Jul 2, 2019·Journal of Speech, Language, and Hearing Research : JSLHR·Marta Białecka-PikulDaniela K O'Neill
Jul 18, 2019·Biology Letters·Marlen FröhlichCarel P van Schaik
Apr 12, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Susan C Johnson
Nov 23, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Katja Liebal, Josep Call
Feb 14, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Henrike Moll, Michael Tomasello
Sep 17, 2013·American Journal of Primatology·Kim A BardKelly McDonald
Apr 2, 2014·American Journal of Speech-language Pathology·Laura J HahnKandace K Fleming
May 6, 2014·Frontiers in Psychology·Wim T J L PouwFred Paas
May 2, 2014·Frontiers in Psychology·Heather L Ramsdell-Hudock

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