PMID: 11334205May 4, 2001Paper

Conditioned blood reperfusion during angioplasty (CoBRA) treatment of acute myocardial infarction

Perfusion
M B PatelW W O'Neill

Abstract

Acute myocardial infarct (MI) results in ischemia distal to lesions which puts heart muscle at risk for reperfusion injury (RI). Neutrophils, platelets and complement are putative mediators of RI. Recent advances in filtration technology provide integrated neutrophil and platelet removal together with complement-attenuating properties in a single blood-conditioning device. The present study characterizes the properties of a blood-conditioning filter and describes its clinical effect when used in conjunction with active hemoperfusion for acute MI. The filter reduces leukocytes by 99.9998 +/- 0.0002% (p<0.0001) and platelets by 99.9934 +/- 0.0069% (p<0.0001). Human plasma, derived from heparinized blood that was 'conditioned' by filtration, was studied using the Langendorff isolated rabbit heart preparation. The deposition of membrane attack complex and the resultant functional myocardial impairments [reflected in hemodynamic and biochemical measurements, including developed pressure, coronary blood flow, lymph-derived myocardial creatine kinase (CK)] are significantly attenuated by blood conditioning. Integration of the blood-conditioning filter into an active hemoperfusion system during primary percutaneous transluminal coronar...Continue Reading

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Citations

Dec 23, 2003·The Journal of Thoracic and Cardiovascular Surgery·Bradley S AllenZhongtou Tan
Mar 27, 2003·The Journal of Thoracic and Cardiovascular Surgery·Bradley S AllenLouis J Ignarro
Sep 22, 2001·Perfusion·S J Morris
Jun 2, 2017·Cardiovascular Diabetology·Isabella RussoPasquale Pagliaro
Jan 21, 2020·Medical Hypotheses·A BarzycA Cudnoch-Jędrzejewska

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