PMID: 2501815Jan 1, 1989Paper

Conditioned emotional responding under diazepam: a psychophysiological study of state dependent learning

Psychopharmacology
H H JensenJ C Poulsen

Abstract

An experimental study on 34 healthy male volunteers demonstrated that a therapeutic dose of diazepam (15 mg PO) influenced the reproduction of a conditioned emotional response (skin conductance activity) on subsequent test days. This effect depended upon the pharmacological state present at acquisition, and was in accordance with a drug-dissociation interpretation of diazepam's amnesic effect. The results are interpreted as an example of diazepam state-dependency effects upon development of behavioral tolerance to stress. The clinical consequence of the results indicates that patients under diazepam medication will to a certain degree be deprived of the ability to develop appropriate coping strategies. It is concluded that combining psychotherapy with diazepam treatment may have the opposite effects to those intended.

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Citations

Jan 1, 1991·Psychopharmacology·R HensmanJ F Deakin
Jun 8, 2006·Psychopharmacology·Catherine M Brignell, H Valerie Curran
Jul 19, 2001·The Journal of Veterinary Medical Science·T KikusuiY Mori
Sep 4, 1999·Journal of Psychopharmacology·J S HellewellJ F Deakin
Aug 18, 2017·Learning & Memory·Mariah A A MeyerJelena Radulovic
Apr 17, 2018·Current Behavioral Neuroscience Reports·Jelena Radulovic

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