Conditioned locomotion induced by unilateral intrastriatal administration of apomorphine: D(2) receptor activation is critical but not the expression of the unconditioned response

Brain Research
Flávia Regina Cruz DiasMarinete Pinheiro Carrera

Abstract

The present study examined the role of D(1) and D(2) receptors in the conditioning of apomorphine-induced locomotor behavior. A Pavlovian conditioning protocol was used in which rats received 5 daily intrastriatal apomorphine treatments paired or unpaired to an open-field environment followed, 2 days later, by a saline test for conditioning. In the conditioning induction phase, the intrastriatal apomorphine treatment increased locomotor activity expressed as an increased number of sectional crossings and rearings. In the conditioning test, the apomorphine-paired group had significantly higher locomotor activity than the unpaired and vehicle groups, consistent with the development of a conditioned locomotor response. The concomitant blockade of D(1) and D(2) receptors with D(1) (SCH23390) and D(2) (sulpiride) antagonists prevented the apomorphine-induced behavioral response during the induction phase and in the conditioning test. Pretreatment with the D(1) antagonist SCH 23390 also blocked the apomorphine-induced behavioral response during the induction phase but did not block the apomorphine conditioned response. Pretreatment with the selective D(2) antagonist sulpiride blocked the apomorphine behavioral response during the ind...Continue Reading

References

Jun 28, 1992·Annals of the New York Academy of Sciences·C P O'BrienR Ehrman
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Sep 1, 1967·The Journal of Pharmacy and Pharmacology·N E AndénT Hökfelt
Sep 1, 1982·Psychological Review·R Eikelboom, J Stewart
Jan 1, 1994·Neuroscience and Biobehavioral Reviews·A Cerbone, A G Sadile
Jan 1, 1996·Critical Reviews in Neurobiology·S P WiseC R Gerfen
Sep 23, 1997·Pharmacology, Biochemistry, and Behavior·I D SmithR J Beninger
Dec 31, 1997·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·F J WhiteX T Hu
Jun 17, 1998·Brain Research·M Pinheiro CarreraC Tomaz
Jun 12, 2003·Behavioural Brain Research·Norman M White, Juan A Salinas

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Citations

Feb 22, 2008·Brain Research·Qing ZengJianren Mao
May 19, 2017·Journal of Forensic Sciences·Marta CippitelliMariano Cingolani

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