PMID: 2508151Jan 1, 1989Paper

Conditioned place aversion produced by FG 7142 is attenuated by haloperidol

Psychopharmacology
G Di Scala, G Sandner

Abstract

A place conditioning paradigm was used to examine the affective properties of FG 7142, a benzodiazepine receptor inverse agonist. At the highest dose tested (10 mg/kg, IP), FG 7142 produced a significant place aversion to the drug-paired compartment. In a second experiment, haloperidol injections were given before FG 7142. It was found that haloperidol (0.2 mg/kg) significantly reduced the measured conditioned place aversion produced by FG 7142, without exhibiting any aversive or rewarding effects by itself. These results suggest that dopamine receptors are involved in the learning or expression of conditioned place aversion induced by benzodiazepine receptor inverse agonists.

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Citations

Jun 24, 1992·European Journal of Pharmacology·M SalaE Gori
Apr 1, 1992·Pharmacology, Biochemistry, and Behavior·G Di ScalaG Sandner
Sep 1, 1992·Pharmacology, Biochemistry, and Behavior·F O RisingerC L Cunningham
Jul 1, 1993·Behavioral and Neural Biology·P OberlingG Sandner
Jan 1, 1996·Behavioural Brain Research·S M Meehan, M D Schechter
Nov 26, 2002·Behavioural Brain Research·Gaetano Di Chiara
Mar 22, 2005·The Australian and New Zealand Journal of Psychiatry·Geoff WaghornRobert King
Apr 1, 1992·Alcoholism, Clinical and Experimental Research·D V GauvinF A Holloway
Aug 23, 2011·Behavioural Brain Research·Oruc AllahverdiyevNurhan Enginar
Jan 1, 1993·Neuroscience and Biobehavioral Reviews·M D Schechter, D J Calcagnetti
Dec 27, 1994·European Journal of Pharmacology·D BraidaM Sala
Sep 5, 2018·Reviews in the Neurosciences·Marcus L Brandão, Norberto C Coimbra

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