Conditioned place-preference analysis in the goldfish with the H1 histamine antagonist chlorpheniramine

Brain Research Bulletin
Rosana MattioliR E Spieler

Abstract

The aim of this study was to investigate whether the histamine H1-receptor blocker, chlorpheniramine (CPA), has a reinforcing effect in goldfish. We used a place-preference procedure in an aquarium with two chambers colored black and white. On day 1, the animals were placed in the test chamber for 10 min for habituation. On day 2, they were placed in the start compartment for 30 s, the sliding doors were opened, and the time spent in each compartment was recorded over the 10 min to determine the natural compartment preference for each animal. On day 3, they were injected either with 0.1, 0.4, 1.0, or 4.0 mg/kg of CPA or only with vehicle and placed in the less preferred compartment for 25 min. On day 4, the animals were placed in the start compartment and the time spent in each compartment during the 10-min test period was recorded again. The groups treated with 1.0 and 4.0 mg/kg of CPA, spent significantly more time in the compartment in which they experienced the drug effect than the group treated with vehicle. On the other hand, the group treated with 0.4 mg/kg spent significantly less time in the drug-paired compartment. The results indicate a biphasic effect of CPA. Considering that there is evidence that low doses of CPA ...Continue Reading

References

Jun 1, 1992·Drug and Alcohol Dependence·P M Beardsley, R L Balster
Aug 1, 1991·The Journal of Comparative Neurology·N InagakiH Wada
Jan 1, 1988·Psychopharmacology·J M White, G R Rumbold
Jun 19, 1981·European Journal of Pharmacology·A Wauquier, C J Niemegeers
Dec 1, 1996·Behavioural Brain Research·P Segura-TorresI Morgado-Bernal

❮ Previous
Next ❯

Citations

May 22, 2003·Pharmacology, Biochemistry, and Behavior·Alison G HalpertRichard J Beninger
Dec 9, 2003·Behavioural Brain Research·F R FaganelloR Mattioli
May 9, 2000·Progress in Neuro-psychopharmacology & Biological Psychiatry·C C MedalhaR Mattioli
Dec 5, 2002·Brain Research Bulletin·Tiffany A BurnsRichard E Spieler
Mar 5, 2011·Nature Protocols·Priya MathurSu Guo
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·T Darland, J E Dowling
Jan 12, 2010·Behavioural Brain Research·E DereJ P Huston
Aug 28, 2004·Neuroscience Letters·Aline Cristina Piratello, Rosana Mattioli
Aug 1, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Flávia Roberta Faganello, Rosana Mattioli
Apr 25, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Luciana Pereira do Vale Cofiel, Rosana Mattioli
Sep 21, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Anna Carolyna GianlorençoRosana Mattioli
Feb 17, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L P V Cofiel, R Mattioli
Mar 31, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D C GarçãoR Mattioli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.