Conditioned place preference in the corral: a procedure for measuring reinforcing properties of drugs.

Journal of Neuroscience Methods
R U HasenöhrlJ P Huston

Abstract

A novel conditioned place preference (CPP) method is described. The behavioral testing apparatus is a circular open field consisting of 4 uniform quadrants that are equally preferred by the rats prior to drug treatment. In an illustrative experiment, rats received an i.p. injection of either morphine (10 mg/kg), substance P (50 micrograms/kg) or vehicle (phosphate-buffered 0.01 M acetic acid in saline) on 3 consecutive days and were placed into their assigned treatment quadrant. Four animals were simultaneously treated with the aid of barriers, which restricted each rat to its treatment quadrant. On the test for CPPs, when provided a choice between the 4 quadrants, rats treated with morphine and substance P exhibited preferences for the quadrant which had been paired with the drugs, illustrating the usefulness of this procedure for assessing the reinforcing properties of the two drugs. Gross locomotor activity was not influenced by either treatment. The advantages of this version of the CPP method over the conventional shuttle-box procedures are discussed.

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Citations

Jun 6, 1995·European Journal of Pharmacology·N Wongwitdecha, C A Marsden
Mar 1, 1996·Pharmacology, Biochemistry, and Behavior·N Wongwitdecha, C A Marsden
May 1, 1992·Journal of Neuroscience Methods·J Krauth
Jan 23, 1995·Behavioural Brain Research·J P Huston, R U Hasenöhrl
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Feb 7, 2013·Trends in Pharmacological Sciences·Joseph P HustonChristian P Müller
Jun 27, 2009·Behavioural Brain Research·Erika KertesLászló Lénárd
Sep 20, 2015·Behavioural Brain Research·K LászlóL Lénárd
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Jun 14, 2018·PloS One·Ryo SogaHirokazu Takahashi
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