Conditioned release of corticosterone by contextual stimuli associated with cocaine is mediated by corticotropin-releasing factor

Brain Research
A C DeVriesA Pert

Abstract

Elevated blood concentrations of corticosterone (CORT), an adrenal steroid associated with stress responses, is one of the endocrine correlates of cocaine treatment. Experiment 1 confirmed and extended previous findings that chronic cocaine treatment does not alter corticosteroid responses to cocaine. In Experiment 2, conditioned endocrine effects of cocaine were examined in three groups of rats after 7 consecutive days of treatment. Cocaine-induced conditioning was achieved using a simple contextual design. In group 1 (paired), rats were injected with cocaine (30 mg/kg), then immediately placed into a locomotor activity chamber for 30 min. One hour after the rats were returned to their home cages, they received an injection of saline. In group 2 (unpaired), rats were injected with saline, then immediately placed into a locomotor activity chamber for 30 min. One hour after the rats were returned to their home cages, they received an injection of cocaine (30 mg/kg). Rats in group 3 (control) received only saline injections, but otherwise were treated as animals in the other treatment groups. On the test day (Day 8), all rats were placed immediately into the locomotor apparatus for 30 min prior to collection of a blood sample. Bl...Continue Reading

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Citations

Dec 6, 2001·European Journal of Pharmacology·O Gurkovskaya, N E Goeders
Mar 20, 2002·Pharmacology, Biochemistry, and Behavior·Robert J CareyErnest Damianopoulos
Sep 24, 1999·Pharmacology, Biochemistry, and Behavior·J R Mantsch, N E Goeders
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Jan 30, 2004·Psychoneuroendocrinology·Pascale Gisquet-VerrierCarmen Sandi
Jul 26, 2011·Biological Psychiatry·Rachel J Smith, Gary Aston-Jones
Dec 9, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Suzanne Erb
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Mar 10, 2015·Physiology & Behavior·Ann E Egan, Yvonne M Ulrich-Lai
Dec 12, 2012·British Journal of Health Psychology·Irina L G TodorovaElitsa Dimitrova
Jan 23, 2002·Molecular Psychiatry·G R UhlI Sora
Dec 31, 2004·The American Journal of Drug and Alcohol Abuse·Debra S HarrisS Paul Berger
Jan 17, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jessica A HigginbothamRita A Fuchs
Sep 2, 2018·Trends in Neurosciences·Elizabeth V Goldfarb, Rajita Sinha

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