Conditioned Reward of Opioids, but not Psychostimulants, is Impaired in GABA-A Receptor δ Subunit Knockout Mice

Basic & Clinical Pharmacology & Toxicology
Milo S SiivonenEsa R Korpi

Abstract

Extrasynaptic δ subunit-containing γ-aminobutyric acid type A receptors (δ-GABAA Rs) are emerging as targets for a number of neuropsychopharmacological drugs, including the direct GABA site agonist gaboxadol and neuroactive steroids. Among other regions, these δ-GABAA Rs are functionally expressed in the ventral tegmental area (VTA), the cell body region of mesocorticolimbic dopamine (DA) system important for motivated behaviours, and in the target region, the nucleus accumbens. Gaboxadol and neurosteroids induce VTA DA neuron plasticity ex vivo, by inhibiting the VTA GABA neurons, and aversive place conditioning, which are absent in the δ-GABAA R knockout mice (δ-KO). It is not known whether δ-GABAA Rs are important for the effects of other drugs, such as opioids (that also inhibit GABA neurons) and stimulants (that primarily elevate monoamine levels). Here, we used δ-KO mice and conditioned place preference (CPP) test to study the rewarding effects of morphine (20 mg/kg), methamphetamine (1 mg/kg) and mephedrone (5 mg/kg). Morphine-induced nociception was also assessed using tail-flick and hot-plate tests. We found that the δ-KO mice failed to express morphine-induced CPP, but that they were more sensitive to morphine-induced...Continue Reading

References

Sep 1, 1995·Journal of Pharmacological and Toxicological Methods·L LangermanG J Grant
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·P V PiazzaH Simon
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·R M MihalekG E Homanics
Jul 18, 2002·Epilepsia·Igor SpigelmanRichard W Olsen
Oct 18, 2002·Neuron·Aki LaaksoMarc G Caron
Nov 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Brandon M StellIstvan Mody
Nov 20, 2003·Proceedings of the National Academy of Sciences of the United States of America·M WallnerR W Olsen
Mar 2, 2005·Nature Reviews. Neuroscience·Mark Farrant, Zoltan Nusser
Jun 16, 2005·Progress in Neurobiology·David SulzerAurelio Galli
Sep 27, 2005·Pharmacology & Therapeutics·Charles P O'Brien, Eliot L Gardner
Nov 8, 2005·The Journal of Pharmacology and Experimental Therapeutics·Cecilia M BorgheseR Adron Harris
Apr 27, 2007·Nature·Fereshteh S NugentJulie A Kauer
May 10, 2007·Nature Protocols·Christopher L CunninghamPeter A Groblewski
Oct 20, 2007·Nature Reviews. Neuroscience·Julie A Kauer, Robert C Malenka
Jun 20, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Anne E HeikkinenEsa R Korpi
Sep 2, 2008·Neuropharmacology·Richard W Olsen, Werner Sieghart
Sep 12, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Emanuela ArgilliAntonello Bonci
Mar 14, 2009·Journal of Psychopharmacology·B C JonesJ C Cassel
Oct 16, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Delia BelelliDavid W Cope
Dec 25, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dev ChandraEsa R Korpi
Feb 12, 2010·Nature·Kelly R TanChristian Lüscher
Nov 13, 2010·Psychopharmacology·Fabrizio SchifanoUNKNOWN ReDNet Research Groups
Dec 16, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jhimly SarkarJamie Maguire
Mar 27, 2012·Neuron·Kelly R TanChristian Lüscher
Apr 13, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elena VashchinkinaEsa R Korpi
Oct 16, 2012·Nature·Stephan LammelRobert C Malenka
Sep 13, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Murray B HerdDelia Belelli
Oct 1, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Elena VashchinkinaEsa R Korpi
Jan 17, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Edward P MaguireJeremy J Lambert

❮ Previous
Next ❯

Citations

Jun 24, 2020·Peptides·Richard J Bodnar
May 18, 2021·Frontiers in Pharmacology·Milo GrotellEsa R Korpi
Jul 9, 2021·Frontiers in Pharmacology·Milo GrotellEsa R Korpi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.