Conditioned social preference, but not place preference, produced by intranasal oxytocin in female mice

Behavioral Neuroscience
Yutaka Kosaki, Shigeru Watanabe

Abstract

Oxytocin (OT) has been implicated in a variety of mammalian reproductive and social behaviors, and the use of intranasal OT for clinical purposes is on the rise. However, basic actions of OT, including the rewarding or reinforcing properties of the drug, are currently not fully understood. In this study, the authors investigated whether intranasally administered OT has different reinforcing properties for social and nonsocial stimuli and whether such effects are variable between male and female subjects. Conditioned social preference (CSP) and conditioned place preference (CPP) paradigms were used to examine social and nonsocial reinforcing properties of OT. In CSP, the presence of a same-sex unfamiliar conspecific was repeatedly paired with intranasal OT, while a different conspecific was associated with saline. The reinforcing effect of OT was assessed in a postconditioning choice test under a drug-free condition. In CPP, the 2 conspecifics were replaced with nonsocial black and white compartments. The authors found that intranasal OT (12 μg) in females supported the formation of CSP (Experiment 1) but not CPP (Experiment 3). Neither CSP (Experiment 2) nor CPP (Experiment 4) was formed in males. Extended conditioning with hig...Continue Reading

Citations

Dec 21, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alberto GalbuseraAlessandro Gozzi
Mar 29, 2018·Journal of Neurodevelopmental Disorders·R K GreeneG S Dichter
Jul 4, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Johnathan M BorlandH Elliott Albers
Oct 1, 2020·Cellular and Molecular Life Sciences : CMLS·Anne-Kathrin GellnerRené Hurlemann
Apr 30, 2019·Frontiers in Physiology·Lauren V RitersJeremy A Spool
Nov 24, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Johnathan M BorlandH Elliott Albers
Feb 12, 2021·Journal of Neurochemistry·Antonia ManducaViviana Trezza
May 3, 2021·BMC Neuroscience·Stanislav M CherepanovHaruhiro Higashida

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