Conditioned stimulus preference after acetaldehyde but not ethanol injections

Pharmacology, Biochemistry, and Behavior
Etienne Quertemont, P De Witte

Abstract

Acetaldehyde, the first ethanol metabolite, has been suggested to mediate some of the behavioral effects of ethanol and particularly its reinforcing properties, although this later hypothesis remains extremely controversial. While several studies demonstrated the reinforcing effects of brain acetaldehyde, blood acetaldehyde accumulation is believed to be primarily aversive. In the present study, a conditioned reinforcement procedure has been used to investigate the reinforcing and/or aversive effects of intraperitoneal injections of both acetaldehyde and ethanol in Wistar rats. An olfactory stimulus was paired with daily injections of either ethanol (0, 0.25, 0.5, 1 and 2 g/kg) or acetaldehyde (0, 10, 20, 100 and 150 mg/kg). After eight conditioning sessions, all rats were tested for their stimulus preference or aversion. The results show that conditioning with small, 0.25 and 0.5 g/kg, ethanol doses induced neither preference nor aversion for the olfactory cue. In contrast, higher ethanol doses (1.0 and 2.0 g/kg) resulted in significant stimulus aversions. Acetaldehyde conditioning led to a biphasic stimulus preference, with a maximal preference around 20 mg/kg acetaldehyde. No evidence of aversive effects was found with incre...Continue Reading

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Citations

Mar 17, 2004·Trends in Pharmacological Sciences·Etienne Quertemont, Sophie Tambour
Apr 12, 2003·Drug and Alcohol Dependence·Etienne QuertemontPhilippe De Witte
Jun 18, 2002·Alcoholism, Clinical and Experimental Research·Etienne Quertemont, Kathleen A Grant
Mar 19, 2014·Pharmacology, Biochemistry, and Behavior·Christian BrabantEtienne Quertemont
Mar 24, 2012·Alcohol·Alessandra T PeanaMarco Diana
Dec 17, 2008·Drug and Alcohol Dependence·Paolo EnricoMarco Diana
Nov 6, 2007·Alcohol·Michael E NizhnikovNorman E Spear
Feb 17, 2005·Alcoholism, Clinical and Experimental Research·Etienne QuertemontMarco Diana
Jul 28, 2005·Alcoholism, Clinical and Experimental Research·Laura FontCarlos M G Aragon
Sep 13, 2005·Alcoholism, Clinical and Experimental Research·Etienne QuertemontRoberta J Ward
Nov 11, 2008·Annals of the New York Academy of Sciences·Marco DianaPaolo Enrico
Oct 24, 2008·Alcoholism, Clinical and Experimental Research·Alessandra T PeanaMarco Diana
Feb 10, 2011·Alcoholism, Clinical and Experimental Research·Donatella SircaMarco Diana
May 1, 2008·Alcoholism, Clinical and Experimental Research·Lutske TampierYedy Israel
Nov 16, 2007·The European Journal of Neuroscience·M MelisM Diana
Oct 3, 2006·Alcoholism, Clinical and Experimental Research·Elizabeth FernandezRandy Strong
Aug 10, 2011·Neuroscience and Biobehavioral Reviews·Mercè CorreaElio Acquas
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Mar 26, 2003·Psychopharmacology·M Dolores EscarabajalEtienne Quertemont
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May 30, 2017·Frontiers in Behavioral Neuroscience·Alessandra T PeanaElio Acquas
Feb 25, 2017·Frontiers in Behavioral Neuroscience·Anna BrancatoCarla Cannizzaro
Nov 29, 2016·Journal of Experimental Neuroscience·Alessandra T PeanaElio Acquas

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