Conditioned taste aversion produced by cyclosporine A: concomitant reduction in lymphoid organ weight and splenocyte proliferation

Physiology & Behavior
M S ExtonM Schedlowski

Abstract

The classical conditioning of immune parameters is commonly conducted within a conditioned taste aversion (CTA) paradigm. In this study, the immunosuppressive drug cyclosporine A (CsA) was investigated for its ability to produce both taste aversion to a novel stimulus and conditioned alterations in immune functioning. The paradigm comprised the pairing of a 0.2% saccharin solution (the conditioned stimulus; CS) with an intraperitoneal injection of 20 mg/kg CsA (the unconditioned stimulus; UCS). Upon saccharin re-presentation, a marked reduction in fluid consumption was observed, indicating aversion to the novel substance (=CTA). By using a single CsA/saccharin pairing the CTA lasted for one CS representation. However, by implementing three pairings, this effect could be extended for up to seven representations. No noticeable difference was recorded by adjusting the saccharin representation from every consecutive day to every second day. The most effective paradigm in creating CTA was subsequently investigated for its effectiveness in producing conditioned immune alterations. Animals were killed on the day of the third CS re-presentation, and immune functions assessed. Conditioned animals displayed a significant reduction in thy...Continue Reading

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Citations

Sep 2, 1998·Transplantation Proceedings·M S ExtonM Schedlowski
Jun 25, 1999·Neuroscience Letters·C V BorlonganS Watanabe
May 18, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Sabine VitsManfred Schedlowski
Jul 30, 2014·Pharmaceutical Development and Technology·Ahmed S ZidanTamer M Shehata
Aug 23, 2019·Physiological Reviews·Martin HadamitzkyManfred Schedlowski
Dec 24, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gustavo Pacheco-LópezManfred Schedlowski

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