Conditioned taste aversions support drug discrimination learning at low dosages of morphine

Behavioral and Neural Biology
D M Skinner, G M Martin

Abstract

The present experiment shows that a conditioned taste aversion procedure can support discrimination learning at dosages of morphine comparable to those required to produce motivational effects. Sprague-Dawley rats were injected with 4.0 mg/kg morphine sulfate prior to a saccharin-lithium chloride pairing, and physiological saline prior to a saccharin-saline pairing. The rats avoided the saccharin solution following the administration of morphine and consumed significantly more saccharin following saline administration after four discrimination cycles. After this initial discrimination the subjects were trained with progressively lower doses of morphine. Discrimination learning was apparent at doses of 2.0, 1.5, 1.0, 0.75 and 0.5 mg/kg. Animals initially trained with 1.0 mg/kg morphine also learned the discrimination but required 10 training cycles. After this initial discrimination the subjects were trained with progressively lower dosages of morphine and showed a discrimination at a dosage of 0.5 mg/kg.

References

Jan 1, 1990·Journal of Experimental Psychology. Animal Behavior Processes·G M MartinD van der Kooy
Feb 1, 1985·Drug and Alcohol Dependence·S G Holtzman
Aug 1, 1982·Pharmacology, Biochemistry, and Behavior·J M WitkinR B Carter

Citations

Jul 1, 1994·Pharmacology, Biochemistry, and Behavior·S T Smurthwaite, A L Riley
Jan 1, 1995·Pharmacology, Biochemistry, and Behavior·A TomieL L Peoples

Related Concepts

Metazoa
Association Learning
Avoidance Learning
Conditioned Reflex
Cues
Discrimination Learning
Dose-Response Relationship, Drug
Water Consumption
Morphine Sulfate (2: 1), Pentahydrate
Retention (Psychology)

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