Conditioning lesions enhance axonal regeneration of descending brain neurons in spinal-cord-transected larval lamprey

The Journal of Comparative Neurology
Lei ZhangAndrew D McClellan

Abstract

In larval lamprey, with increasing recovery times after a transection of the rostral spinal cord, there is a gradual recovery of locomotor behavior, and descending brain neurons regenerate their axons for progressively greater distances below the transection site. In the present study, spinal cord "conditioning lesions" (i.e., transections) were performed in the spinal cord at 30% body length (BL; normalized distance from the head) or 50% BL. After various "lesion delay times" (D), a more proximal spinal cord "test lesion" (i.e., transection) was performed at 10% BL, and then, after various recovery times (R), horseradish peroxidase was applied to the spinal cord at 20% BL to determine the extent of axonal regeneration of descending brain neurons. Conditioning lesions at 30% BL, lesion delay times of 2 weeks, and recovery times of 4 weeks (D-R = 2-4 group) resulted in a significant enhancement of axonal regeneration for the total numbers of descending brain neurons as well as neurons in certain brain cell groups compared to control animals without conditioning lesions. Experiments with hemiconditioning lesions, which reduce interanimal variability, confirmed that conditioning lesions do significantly enhance axonal regeneration...Continue Reading

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Citations

Mar 5, 2016·Experimental Neurology·Jeffrey P Rasmussen, Alvaro Sagasti
May 28, 2014·Journal of Neuroscience Methods·Gunja K PathakSameer B Shah
Jun 2, 2006·International Review of Neurobiology·Rüdiger SchweigreiterRobert M Gould

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