PMID: 1034594Sep 1, 1976

Conditioning of emotional behavior caused by hypothalamic stimulation (4). Effects of drugs on conditioned avoidance and escape behavior

Nihon yakurigaku zasshi. Folia pharmacologica Japonica
S YanauraT Hosokawa


In the present study, effects of psychotropic drugs were analyzed by observing avoidance and escape behavior or rabbits under hypothalamic electrical stimulation. In avoidance behavior, chlorpromazine (CPZ) and diazepam (DZP) depressed avoidance response and extended avoidance response latency and head movement latency. Autonomic behavior such as opening of palpebral fissure and pupil size were also delayed. The locus of movement and count of head movement were depressed by the administration of each drug. On the other hand, unlike CPZ, DZP extended escape response latency. On escape behavior, effects of CPZ and DZP were apparently different. Unlike CPZ, DZP induced avoidance behavior and increased locus of movement. With methamphetamine, no avoidance behavior was observed, but under conditional stimulation, the behavior and the escape response latency were decreased. Chlordiazepoxide induced avoidance behavior.

Related Concepts

Avoidance Learning
Conditioning (Psychology)
Electric Stimulation Technique
Escape Reaction
Organum Vasculosum Laminae Terminalis

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.