Conditioning with cyclophosphamide/antithymocyte globulin for allogeneic bone marrow transplantation from HLA-matched siblings in children with severe aplastic anemia

Bone Marrow Transplantation
E AzumaM Sakurai

Abstract

Graft rejection has been a problem after bone marrow transplantation for patients with severe aplastic anemia (SAA). Ten children with SAA were conditioned for bone marrow transplantation from HLA-identical siblings, using cyclophosphamide (CY, 50 mg/kg) plus antithymocyte globulin (ATG, 15 mg/kg) for 4 successive days. Marrow was infused 36 h after the last dose of CY. Cyclosporin A and methotrexate were administered as graft-versus-host disease (GVHD) prophylaxis. All patients achieved durable engraftment at follow-up of 7-41+ months (mean, 25) without significant GVHD. Since investigators have used different sources, doses, and time schedules of ATG, we compared our results with other published reports. We conclude that CY/ATG conditioning is well tolerated and effective in children with SAA.

Citations

Apr 10, 2002·International Journal of Hematology·George E Georges, Rainer Storb
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Dec 3, 2014·Hematology/oncology Clinics of North America·Andrea Bacigalupo
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Jun 28, 2013·Pediatric Hematology and Oncology·Mohammed RamzanAnupam Sachdeva
Apr 13, 2015·International Journal of Hematology·Makoto Murata
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