PMID: 6171871Jan 1, 1981Paper

Conditions for cytomegalovirus stimulation of lymphocytes

Scandinavian Journal of Immunology
B WahrenS Nordlund

Abstract

Lymphocytes from healthy donors or from patients with chronic lymphocytic leukaemia were subjected to live or inactivated cytomegalovirus (CMV) or the mitogen phytohaemagglutinin. No early or late CMV antigens could be demonstrated in the lymphocytes, indicating that neither abortive nor replicative CMV infection takes place. Only cells from CMV antibody-positive leukaemic and non-leukaemic donors were stimulated by CMV to DNA synthesis, with a maximum on day 5. Cells from all individuals responded to phytohaemagglutinin stimulation, the peak of activity occurring on day 3. The stimulation with CMV occurred in T cells and was independent of early CMV antigen production, viral DNA synthesis, or viral replication. CMV is thus not an in vitro lymphocyte mitogen like Epstein-Barr virus but is a very potent antigen for memory T cells.

References

Jan 1, 1975·Intervirology·A Moller-LarsenI Sarov
Nov 1, 1977·The Journal of Infectious Diseases·C R RinaldoM S Hirsch
Nov 17, 1978·Medical Microbiology and Immunology·I SarovH K Andersen
Feb 1, 1979·Infection and Immunity·M J Tocci, S C St Jeor
Feb 1, 1979·The Journal of Infectious Diseases·T FurukawaS A Plotkin
Jan 1, 1979·Scandinavian Journal of Immunology·A G Bird, S Britton
Jan 1, 1979·Scandinavian Journal of Immunology·K H RobèrtE Möller
Jun 1, 1973·Journal of Virology·S St Jeor, F Rapp
Jan 1, 1980·Intervirology·B Wahren, B Oberg

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Citations

Jan 1, 1984·Archives of Virology·B WahrenH Gadler
May 25, 1988·Journal of Immunological Methods·A LaubscherN J Zvaifler
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G P RiceM B Oldstone
Jan 1, 1993·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·T KhavkinD Testa
Apr 1, 1987·Acta Psychiatrica Scandinavica·B Haver
May 23, 1985·Journal of Immunological Methods·M LerouxH Kirchner
Dec 1, 1985·Journal of Virological Methods·P LjungmanV A Sundqvist

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