Conditions required for the antibacterial activity of zidovudine

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
C S Lewin, S G Amyes

Abstract

In a study to determine the conditions required for its antibacterial activity, zidovudine was found to be bactericidal against Escherichia coli and Salmonella typhimurium in nutrient broth over 6 h. Zidovudine was also found to be active against ten clinical isolates of Salmonella and Escherichia coli at 1 mg/l, which is a clinically achievable concentration of the drug. Bacterial protein synthesis was required for the bactericidal activity of zidovudine against both Escherichia coli and Salmonella typhimurium. Zidovudine was found to be inactive against non-dividing bacteria, as it was unable to kill bacteria of either species when they were suspended in PBS.

References

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Citations

Jun 1, 1993·FEMS Immunology and Medical Microbiology·M T MascellinoS Farinelli
Aug 1, 1992·The Journal of Pharmacy and Pharmacology·A J ShepherdC S Lewin
Jan 1, 1993·Antimicrobial Agents and Chemotherapy·S J SperberM P Weinstein
Jul 1, 1990·FEMS Microbiology Letters·C S LewinS G Amyes
Oct 12, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S M S NgC S B Chia
May 7, 2002·Nucleosides, Nucleotides & Nucleic Acids·Guillermo N MoroniMargarita C Briñón

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