Conduct disorder in females is associated with reduced corpus callosum structural integrity independent of comorbid disorders and exposure to maltreatment

Translational Psychiatry
P LindnerS Hodgins

Abstract

The behavioral phenotype and genotype of conduct disorder (CD) differ in males and females. Abnormalities of white matter integrity have been reported among males with CD and antisocial personality disorder (ASPD). Little is known about white matter integrity in females with CD. The present study aimed to determine whether abnormalities of white matter are present among young women who presented CD before the age of 15, and whether abnormalities are independent of the multiple comorbid disorders and experiences of maltreatment characterizing females with CD that may each in themselves be associated with alterations of the white matter. Three groups of women, aged on average 24 years, were scanned using diffusion tensor imaging and compared: 28 with prior CD, three of whom presented ASPD; a clinical comparison (CC) group of 15 women with no history of CD but with similar proportions who presented alcohol dependence, drug dependence, anxiety disorders, depression disorders and physical and sexual abuse as the CD group; and 24 healthy women. Whole-brain, tract-based spatial statistics were computed to investigate differences in fractional anisotropy, axial diffusivity and radial diffusivity. Compared with healthy women, women with...Continue Reading

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Citations

Feb 22, 2017·Journal of the American Academy of Child and Adolescent Psychiatry·Willeke Martine MenksNora Maria Raschle
Mar 3, 2020·Frontiers in Psychiatry·Mika JohansonMarkku Lähteenvuo
Jul 12, 2017·Cognitive, Affective & Behavioral Neuroscience·Meenal BudhirajaSheilagh Hodgins
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Oct 11, 2017·Social Cognitive and Affective Neuroscience·Philip LindnerSheilagh Hodgins
Nov 27, 2020·Journal of Affective Disorders·Daniel T BurleyTimothy J Silk
Dec 14, 2021·Frontiers in Neuroinformatics·Sreevalsan S Menon, K Krishnamurthy

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Methods Mentioned

BETA
dissection
dissections

Software Mentioned

FSL
R
TBSS
fslmeants
FMRIB58
FNIRT
DTIPrep
Tract Based Spatial Statistics ( TBSS

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