PMID: 1194885Jun 1, 1975Paper

Conductance increases produced by bath application of cholinergic agonists to Electrophorus electroplaques

The Journal of General Physiology
H A LesterR E Sheridan

Abstract

When solutions containing agonists are applied to the innervated face of an Electrophorus electroplaque, the membrane's conductance increases. The agonist-induced conductance is increased at more negative membrane potentials. The "instantaneous" current-voltage curve for agonist-induced currents is linear and shows a reversal potential near zero mV; chord conductances, calculated on the basis of this reversal potential, change epsilon-fold for every 62-mV change in potential when the conductance is small. Conductance depends non-linearly on small agonist concentrations; at all potentials, the dose-response curve has a Hill coefficient of 1.45 for decamethonium (Deca) and 1.90 for carbamylcholine (Carb). With agonist concentrations greater than 10(-4) M Carb or 10(-%) M Deca, the conductance rises to a peak 0.5-1.5 min after introduction of agonist, then declines with time; this effect resembles the "desensitization" reported for myoneural junctions. Elapid alpha-toxin, tubocurarine, and desensitization reduce the conductance without changing the effects of potential; the apparent dissociation constant for tubocurarine is 2 X 10(-7) M. By contrast, procaine effects a greater fractional inhibition of the conductance at high negat...Continue Reading

References

Jul 27, 1973·Brain Research·E Nickel, L T Potter
Sep 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·A Karlin
Mar 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·J P Changeux, T R Podleski
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Citations

Dec 29, 1977·Molecular and Cellular Biochemistry·F Hucho, W Schiebler
Jan 30, 1976·Pflügers Archiv : European journal of physiology·P R Adams
Jun 1, 1989·Cellular and Molecular Neurobiology·E L OchoaM G McNamee
Jun 1, 1978·Neuropharmacology·K KaibaraA G Karczmar
Mar 20, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·A L GotterJ R Dedman
Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M WeberJ P Changeux
Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·R E Sheridan, H A Lester
Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A P YoungD S Sigman
Nov 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·S M Dunn, M A Raftery
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M M WhiteN Davidson
Jul 1, 1977·The Journal of General Physiology·N L Lassignal, A R Martin
Mar 1, 1980·The Journal of General Physiology·R Horn, M S Brodwick
Jul 15, 1986·European Journal of Biochemistry·F Hucho
Jun 30, 2011·PLoS Biology·Iwan Zimmermann, Raimund Dutzler
Apr 5, 1976·Biochemical and Biophysical Research Communications·G P HessG E Struve
Nov 14, 1977·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D Colquhoun, A G Hawkes
May 23, 1983·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A Trautmann
Feb 28, 1981·The Journal of Membrane Biology·P R Adams
Nov 1, 1982·British Journal of Pharmacology·P Pennefather, D M Quastel
Feb 6, 1976·Science·N L Lassignal, A R Martin

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