Conductance ratios and cellular identity.

PLoS Computational Biology
Amber E Hudson, Astrid A Prinz

Abstract

Recent experimental evidence suggests that coordinated expression of ion channels plays a role in constraining neuronal electrical activity. In particular, each neuronal cell type of the crustacean stomatogastric ganglion exhibits a unique set of positive linear correlations between ionic membrane conductances. These data suggest a causal relationship between expressed conductance correlations and features of cellular identity, namely electrical activity type. To test this idea, we used an existing database of conductance-based model neurons. We partitioned this database based on various measures of intrinsic activity, to approximate distinctions between biological cell types. We then tested individual conductance pairs for linear dependence to identify correlations. Contrary to experimental evidence, in which all conductance correlations are positive, 32% of correlations seen in this database were negative relationships. In addition, 80% of correlations seen here involved at least one calcium conductance, which have been difficult to measure experimentally. Similar to experimental results, each activity type investigated had a unique combination of correlated conductances. Finally, we found that populations of models that conf...Continue Reading

References

Oct 1, 1992·Journal of Neurophysiology·J R Huguenard, D A McCormick
Feb 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·B K KaangY Furukawa
Oct 1, 1992·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology· Sivasubramanian
Jun 1, 1993·Journal of Neurophysiology·Y V PanchinT A Cleland
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·E MarderJ Golowasch
Jun 1, 1997·Current Opinion in Neurobiology·H BitoR W Tsien
Oct 10, 2002·Neural Networks : the Official Journal of the International Neural Network Society·Eve Marder, Vatsala Thirumalai
Nov 26, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Eve Marder, Astrid A Prinz
Jan 16, 2003·Neuron·Jason N MacLeanRonald M Harris-Warrick
Aug 9, 2003·Journal of Neurophysiology·Bruce R JohnsonRonald M Harris-Warrick
Nov 24, 2004·Nature Neuroscience·Astrid A PrinzEve Marder
Feb 18, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dirk BucherEve Marder
May 11, 2005·Neural Computation·Denis Burdakov
Jul 29, 2005·Journal of Neurophysiology·Jason N MacLeanRonald M Harris-Warrick
Nov 11, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christine M ColvisEric J Nestler
Mar 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mikko VähäsöyrinkiMikko Juusola
Apr 21, 2006·Journal of Neurophysiology·Quentin J M HuysLiam Paninski
May 12, 2006·Journal of Neurophysiology·Adam L TaylorEve Marder
Jul 20, 2006·PLoS Computational Biology·Pablo Achard, Erik De Schutter
Feb 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·I-Feng Peng, Chun-Fang Wu
Jun 5, 2007·Trends in Neurosciences·John R Huguenard, David A McCormick
Jul 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·David J SchulzEve E Marder
Aug 10, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Olga Khorkova, Jorge Golowasch
Sep 15, 2007·Journal of Neurophysiology·Andrey V Olypher, Ronald L Calabrese
May 1, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Adam L TaylorEve Marder
Nov 7, 2009·Frontiers in Neural Circuits·Allen I SelverstonMarcelo Reyes

❮ Previous
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Citations

Jun 20, 2014·PLoS Computational Biology·Anca Doloc-Mihu, Ronald L Calabrese
Jul 20, 2012·Annual Review of Biomedical Engineering·Michael Levin, Claire G Stevenson
Jul 7, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Astrid A Prinz
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Eve Marder
Sep 28, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shunbing Zhao, Jorge Golowasch
Dec 3, 2011·Journal of Computational Neuroscience·Wafa SoofiAstrid A Prinz
Apr 13, 2012·The Journal of Physiology·Amrita X SarkarEric A Sobie
Dec 2, 2015·Journal of Computational Neuroscience·Warren D AndersonRajanikanth Vadigepalli
Jun 8, 2011·Current Opinion in Neurobiology·Ronald M Harris-Warrick
Dec 18, 2014·Current Biology : CB·Astrid A Prinz
May 2, 2013·Journal of Molecular and Cellular Cardiology·Megan A CumminsEric A Sobie
Apr 4, 2015·Journal of Computational Neuroscience·Wafa Soofi, Astrid A Prinz
Jun 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Timothy O'LearyEve Marder
Oct 11, 2016·Current Opinion in Neurobiology·David J Schulz, Brian J Lane
Dec 3, 2014·Current Opinion in Neurobiology·Eve MarderAdriane G Otopalik
Feb 28, 2013·Network : Computation in Neural Systems·Cyrus P BillimoriaJohn T Birmingham
Aug 26, 2016·Journal of Neurophysiology·Horacio G RotsteinJorge Golowasch
Apr 28, 2017·Journal of Neurophysiology·Michael GrayJorge Golowasch
Oct 14, 2010·Physiology·Amber E HudsonAstrid A Prinz
Dec 23, 2011·Journal of Neurophysiology·Rebecca C RoffmanRonald L Calabrese
Sep 21, 2012·Journal of Neurophysiology·Michael S Carroll, Jan-Marino Ramirez
Sep 4, 2015·Journal of Neurophysiology·Ryan M HooperAstrid A Prinz
Jun 2, 2018·Neural Development·Nai-Wen Tien, Daniel Kerschensteiner
Feb 10, 2019·Scientific Reports·Trinh TranJorge Golowasch
Jan 29, 2011·Nature Neuroscience·Eve Marder, Adam L Taylor
Nov 19, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Mohammad Amin Kamaleddin

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