Conducted dilatation to ATP and K+ in rat skeletal muscle arterioles

Acta Physiologica
K A Dora

Abstract

During exercise in humans, circulating levels of ATP and K+ increase at a time when blood flow increases to satisfy metabolic demand. Both molecules can activate arteriolar K+ channels to stimulate vasodilatation; here, it is established whether conducted dilatation is observed in a skeletal muscle bed. Isolated and cannulated rat cremaster arterioles were used to assess both local and conducted responses. Agents were either added to the bath, focally pulse-ejected to the downstream end of arterioles, or in triple-cannulated arterioles, luminally perfused into the downstream branches to assess both local and conducted responses. The endothelium-dependent agonist ACh and the KATP channel opener levcromakalim each stimulated both local and conducted vasodilatation. Focal, bolus delivery of ATP (10 μm) or KCl (33 mm) to the outside of arterioles stimulated a biphasic vasomotor response: rapid vasoconstriction followed by dilatation as each washed away. At lower concentrations of KCl (19 mm), constriction was avoided, and instead, Ba2+ -sensitive local dilatation and conducted dilatation were both observed. Luminal perfusion of ATP avoided constriction and activated P2Y1 receptors stimulating vasodilatation secondary to opening of ...Continue Reading

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Citations

Sep 23, 2016·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Kim A Dora
May 21, 2016·Acta Physiologica·P B L HansenP M Vanhoutte
Dec 31, 2016·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Coral L MurrantNicole M Novielli
Oct 3, 2017·Annual Review of Pharmacology and Toxicology·Donald G WelshMaria Sancho
Aug 26, 2019·Acta Physiologica·Pontus B Persson
Apr 26, 2018·PloS One·Alexandra V Ulyanova, Roman E Shirokov
Dec 12, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Joel D TrinityRussell S Richardson
Feb 5, 2021·European Journal of Applied Physiology·Coral L MurrantKinley S Gee
Apr 6, 2021·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Gaylene M Russell McEvoyGraham M Fraser
Apr 15, 2021·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Nour W GhonaimChristopher G Ellis

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