Conducting a two-stage preference trial: utility and challenges

International Journal of Nursing Studies
Souraya SidaniDana Epstein

Abstract

Treatment preferences reflect individuals' choice of therapy and influence their adherence to treatment and achievement of outcomes. The two-stage partially randomized clinical or preference trial (two-stage PRCT) is an appropriate design for examining the contribution of treatment preferences. It involves a two-stage process for assigning participants to treatments, which is useful to dismantle the effects of the treatments from those of treatment preferences. In this paper, we explain the role of treatment preferences in intervention evaluation research, describe the protocol for implementing the two-stage PRCT, and discuss issues in its application. The issues are encountered in the selection of treatments, assignment of participants and assessment of treatment preferences. Lastly, we propose ways to address the issues.

References

Dec 16, 2000·The British Journal of Psychiatry : the Journal of Mental Science·N BediI Williams
Mar 5, 2003·Social Science & Medicine·Mary R JanevicNoreen M Clark
Sep 6, 2003·BMJ : British Medical Journal·Rebecca E Say, Richard Thomson
Oct 20, 2005·Journal of Epidemiology and Community Health·Ann Bowling, Gene Rowe
Feb 3, 2006·The Gerontologist·Amber M GumJürgen Unützer
Feb 8, 2006·Behaviour Research and Therapy·Nicholas TarrierLynsey Gregg
Sep 13, 2006·Worldviews on Evidence-based Nursing·Souraya SidaniJoyal Miranda
May 9, 2007·General Hospital Psychiatry·Jane L GivensLisa A Cooper
Jul 27, 2007·Research in Nursing & Health·Mary T FoxDavid Streiner
Dec 17, 2008·Medical Care Research and Review : MCRR·Barbara G BokhourLewis E Kazis
May 13, 2009·Research in Nursing & Health·Souraya SidaniJoyal Miranda
Jul 17, 2009·Research in Nursing & Health·Nikhil S PadhyeSandra K Hanneman
Jun 24, 2010·Journal of Empirical Research on Human Research Ethics : JERHRE·Anna H L Floyd, Anne Moyer
Dec 2, 2010·Journal of Clinical Psychology·Joshua K SwiftBarbara M Vollmer
Jan 24, 2012·Lancet·Charles M Morin, Ruth Benca

❮ Previous
Next ❯

Citations

Nov 23, 2016·Statistical Methods in Medical Research·Briana Cameron, Denise A Esserman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.