Conducting clinical studies targeting cognition in psychiatry: guiding principles and design

CNS Spectrums
Tamsyn E Van RheenenKatherine E Burdick

Abstract

Cognitive dysfunction is common in many psychiatric disorders. While it has long been described as a core feature in schizophrenia, more recent data suggest qualitatively similar impairments in patients with bipolar disorder and major depressive disorder. There is compelling evidence to suggest that cognitive impairment contributes directly to functional disability and reduced quality of like across these disorders. As current treatments focus heavily on "primary" symptoms of mood and psychosis, the standard of care typically leaves cognitive deficits unmanaged. With this in mind, the field has recently begun to consider intervening directly on this important symptom domain, with several ongoing trials in schizophrenia. Fewer studies have targeted cognition in bipolar disorder and still fewer in MDD. With progress toward considering this domain as a target for treatment comes the need for consensus guidelines and methodological recommendations on cognitive trial design. In this manuscript, we first summarize the work conducted to date in this area for schizophrenia and for bipolar disorder. We then begin to address these same issues in MDD and emphasize the need for additional work in this area.

References

Dec 6, 2005·Journal of Affective Disorders·Yvonne Paelecke-HabermannBernd Leplow
Apr 15, 2006·The Journal of Nervous and Mental Disease·Katherine E BurdickAnil K Malhotra
Sep 13, 2006·The Journal of Clinical Psychiatry·Michael F Green
Nov 21, 2007·CNS Drugs·Katherine E BurdickAnil K Malhotra
Jan 4, 2008·The American Journal of Psychiatry·Robert S KernStephen R Marder
Jan 4, 2008·The American Journal of Psychiatry·Keith H NuechterleinStephen R Marder
Feb 9, 2010·Psychiatry Research·Bernhard T BauneDavid Mitchell
Apr 1, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Katherine E BurdickAnil K Malhotra
Nov 18, 2011·Journal of Affective Disorders·Rico S C LeeM Antoinette Redoblado-Hodge
Jul 25, 2012·Neuropsychology·Bo Jacob HasselbalchLars Vedel Kessing
Sep 5, 2012·European Psychiatry : the Journal of the Association of European Psychiatrists·B J HasselbalchL V Kessing
Oct 15, 2013·Bipolar Disorders·Tamsyn E Van Rheenen, Susan L Rossell
May 7, 2014·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Philip D HarveyJohn Concato
Oct 3, 2014·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Deanna M Barch, Julia M Sheffield
Nov 26, 2014·Depression and Anxiety·Manuela RussoKatherine E Burdick
Apr 2, 2015·The Journal of Clinical Psychiatry·Katherine E BurdickJoseph R Calabrese
Oct 6, 2015·Journal of Affective Disorders·Jeffrey N MotterJoel R Sneed
Nov 18, 2015·Current Opinion in Psychiatry·Roger S McIntyre, Yena Lee
Jun 9, 2016·Expert Review of Pharmacoeconomics & Outcomes Research·Marci ClarkVanessa Perez
Dec 22, 2016·Journal of Medical Internet Research·Patricia A AreanJoaquin A Anguera
Mar 1, 2017·Psychological Medicine·T E Van RheenenK E Burdick
Oct 28, 2017·Current Opinion in Psychiatry·Matthew J Knight, Bernhard T Baune
Jan 26, 2018·Bipolar Disorders·Olivia M DeanLana J Williams

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Citations

Mar 20, 2020·Current Pharmaceutical Design·Vicent Balanzá-MartínezPilar López-García

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