Conducting extinction in multiple contexts does not necessarily attenuate the renewal of shock expectancy in a fear-conditioning procedure with humans

Behaviour Research and Therapy
David L NeumannStorm E Cory

Abstract

The renewal of Pavlovian-conditioned responses may provide a model for the relapse of fear following extinction-based treatments for anxiety disorders. Renewal can be observed if conditional stimulus (CS) and unconditional stimulus (US) pairings are given in one context, extinction trials of CS presentations in a second context, prior to test trials of CS presentations in the original acquisition context (ABA renewal). We examined ABA renewal in humans by using a fear-conditioning procedure with an unpleasant shock US. A renewal of rated shock expectancy was demonstrated with this procedure. Conducting extinction treatment in multiple contexts was expected to attenuate the renewal effect. However, the renewal of shock expectancy persisted when extinction treatment was given across three or five different contexts. With the current renewal design, learning task, and measure of conditioned behaviour, extinction treatment does not appear to readily generalise to the test context. The use of multiple extinction treatments in a clinical setting may not necessarily reduce the likelihood of relapse via a renewal effect.

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Citations

Dec 7, 2007·Psychopharmacology·Christian Grillon
Dec 13, 2006·Molecular Psychiatry·K M Myers, M Davis
Mar 4, 2014·Neurobiology of Learning and Memory·Joseph E DunsmoorKevin S LaBar
May 28, 2014·Behaviour Research and Therapy·Michelle G CraskeBram Vervliet
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Jan 17, 2016·Behavioural Processes·Valeria V GonzálezMario A Laborda
Sep 24, 2015·Developmental Psychobiology·Kimberly CuevasCarolyn Rovee-Collier
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Dec 25, 2012·Behaviour Research and Therapy·Youssef ShibanAndreas Mühlberger
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Jul 28, 2012·Behaviour Research and Therapy·Siavash Bandarian BaloochMark J Boschen
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Dec 6, 2019·Journal of the Experimental Analysis of Behavior·Michael W SchlundSimon Dymond
Aug 19, 2017·Scientific Reports·Marijn C W KroesElizabeth A Phelps

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