PMID: 7525006Oct 1, 1994Paper

Conduction abnormalities are restricted to the central nervous system in experimental autoimmune encephalomyelitis induced by inoculation with proteolipid protein but not with myelin basic protein

Brain : a Journal of Neurology
J B ChalkM P Pender

Abstract

Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disease of the central nervous system (CNS) and can be induced by inoculation of animals with homogenized CNS tissue or highly purified myelin proteins such as myelin basic protein (MBP) or proteolipid protein (PLP). It is widely studied as a possible animal model of multiple sclerosis. We performed the present neurophysiological study to define the location of nerve conduction abnormalities in EAE induced by immunization with PLP (PLP-EAE) and in EAE induced by immunization with MBP (MBP-EAE) in the Lewis rat. In rats with tail weakness due to acute PLP-EAE, conduction was normal in the spinal nerve roots and peripheral nerves but there was evidence of conduction block in a high proportion of the fibres in the dorsal columns of the lumbosacral spinal cord. In contrast, in acute MBP-EAE, there was conduction block in a high proportion of fibres in the sacral dorsal and ventral roots of the peripheral nervous system (PNS) and in the dorsal columns of the lumbosacral spinal cord. The distribution of nerve conduction abnormalities is consistent with previous histological studies showing that inflammation and primary demyelination are restricted to the...Continue Reading

Citations

Dec 22, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K J Smith, W I McDonald
May 12, 2006·Neurological Research·Kourosh RezaniaBetty Soliven
May 27, 2008·Journal of Autoimmunity·Judith M Greer, Michael P Pender
Nov 25, 2005·Muscle & Nerve·Stefano AmadioUbaldo del Carro
Oct 21, 2003·The Journal of Pharmacology and Experimental Therapeutics·Susan E HanakMark D Black
Apr 17, 2003·British Medical Bulletin·Mark F LythgoeNeil G Harris
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Judith M GreerMichael P Pender

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